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1
Advances in the development of a screening test for variant Creutzfeldt-Jakob disease.
Expert Opin Med Diagn. 2008 Feb;2(2):207-19. doi: 10.1517/17530059.2.2.207.
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3
Identification of seven haplotypes of the caprine PrP gene at codons 127, 142, 154, 211, 222 and 240 in French Alpine and Saanen breeds and their association with classical scrapie.在法国阿尔卑斯山羊和萨能山羊品种中鉴定127、142、154、211、222和240密码子处山羊朊蛋白基因的七种单倍型及其与经典羊瘙痒病的关联。
J Gen Virol. 2009 Mar;90(Pt 3):769-776. doi: 10.1099/vir.0.006114-0.
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Protective effect of the AT137RQ and ARQK176 PrP allele against classical scrapie in Sarda breed sheep.AT137RQ和ARQK176 PrP等位基因对撒丁岛品种绵羊经典痒病的保护作用。
Vet Res. 2009 May-Jun;40(3):19. doi: 10.1051/vetres/2009002. Epub 2009 Jan 27.
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Histidine at codon 154 of the prion protein gene is a risk factor for Nor98 scrapie in goats.朊病毒蛋白基因第154密码子处的组氨酸是山羊感染Nor98羊瘙痒病的一个风险因素。
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检测巴基斯坦绵羊（Damani 和 Hashtnagri）和山羊（Kamori 和本地卷毛）品种的朊病毒基因中的四个新多态性。

Detection of four novel polymorphisms in PrP gene of Pakistani sheep (Damani and Hashtnagri) and goats (Kamori and Local Hairy) breeds.

机构信息

University of Veterinary and Animal Sciences, Lahore, Pakistan.

出版信息

Virol J. 2011 May 20;8:246. doi: 10.1186/1743-422X-8-246.

DOI:10.1186/1743-422X-8-246
PMID:21595993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3120785/
Abstract

Scrapie is a fatal neurodegenerative disorder of sheep and goats caused by post-translational conformational change in the host-encoded prion protein (PrPC). Susceptibility or resistance to scrapie has been associated with the presence of polymorphisms in the prion protein (PrP) gene. In the present study, we analyzed the PrP gene sequence to determine the frequency of polymorphisms in 56 sheep (28 each from Damani and Hashtnagri breeds) and 56 goats (28 each from Kamori and Local Hairy breeds). A total of 7 amino acid polymorphisms were detected in the PrP gene for sheep and 4 for goats. These amino acid polymorphisms were combined in 13 alleles and 15 genotypes in sheep and 5 alleles and 6 genotypes in goats. The overall frequency of the most sheep scrapie-resistant polymorphism (Q171R) was calculated to be 0.107. The most scrapie-susceptible polymorphism (A136V) was not detected in any of the studied sheep. The overall frequency of scrapie-associated polymorphism (H143R) in goats was found to be 0.152. Along with already known amino acid polymorphisms, two novel polymorphisms were also detected for each of sheep (Q171N and T191I) and goats (G22C and P63L). However, the overall frequency of these polymorphisms was extremely low.

摘要

瘙痒病是绵羊和山羊的一种致命神经退行性疾病，由宿主编码的朊病毒蛋白（PrPC）的翻译后构象变化引起。对瘙痒病的易感性或抗性与朊病毒蛋白（PrP）基因中的多态性的存在有关。在本研究中，我们分析了 PrP 基因序列，以确定 56 只绵羊（Damani 和 Hashtnagri 品种各 28 只）和 56 只山羊（Kamori 和 Local Hairy 品种各 28 只）中多态性的频率。在绵羊的 PrP 基因中检测到了总共 7 个氨基酸多态性，而在山羊中则检测到了 4 个。这些氨基酸多态性在绵羊中组合成 13 个等位基因和 15 个基因型，在山羊中组合成 5 个等位基因和 6 个基因型。最抗绵羊瘙痒病的多态性（Q171R）的总体频率计算为 0.107。在任何研究的绵羊中都未检测到最易感染瘙痒病的多态性（A136V）。在山羊中，与瘙痒病相关的多态性（H143R）的总体频率为 0.152。除了已经知道的氨基酸多态性外，还在每只绵羊（Q171N 和 T191I）和山羊（G22C 和 P63L）中检测到了两个新的多态性。然而，这些多态性的总体频率非常低。