新生大鼠大脑中的应激与γ-氨基丁酸受体的长期调节
Neonatal stress and long-term modulation of GABA receptors in rat brain.
作者信息
Bolden S W, Hambley J W, Johnston G A, Rogers L J
机构信息
Department of Physiology, University of New England, Armidale, N.S.W., Australia.
出版信息
Neurosci Lett. 1990 Apr 6;111(3):258-62. doi: 10.1016/0304-3940(90)90271-a.
Neonatal handling, known to have long-term effects on behaviour and neuroendocrine responses to acute stress, has been found to produce a long-term change in gamma-aminobutyric acid (GABA) receptor binding (Bmax) in whole-brain membranes of spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. A significant 10% increase in the binding of [3H] GABA to receptors was evident more than 100 days after handling. There were no differential effects of handling between these two strains, but there was a whole-brain deficit in GABA receptor binding in SHR as compared to WKY animals. Adult corticosterone levels did not correlate with GABA receptor binding.
已知新生儿期的处理对行为以及对急性应激的神经内分泌反应具有长期影响，研究发现，这种处理会使自发性高血压大鼠（SHR）和Wistar-Kyoto大鼠（WKY）全脑膜中γ-氨基丁酸（GABA）受体结合（Bmax）产生长期变化。处理100多天后，[3H] GABA与受体的结合显著增加了10%。这两个品系之间的处理没有差异效应，但与WKY动物相比，SHR存在全脑GABA受体结合缺陷。成年大鼠的皮质酮水平与GABA受体结合无关。
Zotero 插件