Institute of Chemical Industry of Forest Products, CAF, Nanjing 210042, People's Republic of China.
Fitoterapia. 2011 Sep;82(6):834-40. doi: 10.1016/j.fitote.2011.04.009. Epub 2011 May 10.
The hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves were evaluated against carbon tetrachloride induced hepatic damage in Sprague-Dawley rats. The elevated levels of serum ALT, AST, ALP, ALB, TP, HA, LN, TG, and CHO were restored towards normalization significantly by GBP in a dose dependent manner. The biochemical observations were supplemented with histopathological examination of rat liver sections. Meanwhile, GBP also produced a significant and dose-dependent reversal of CCl(4)-diminished activity of the antioxidant enzymes and reduced CCl(4)-elevated level of MDA. In general, the effects of GBP were not significantly different from those of the standard drug Essentiale.
银杏叶多聚戊烯对四氯化碳诱导的 SD 大鼠肝损伤的保护作用。银杏叶多聚戊烯可使血清 ALT、AST、ALP、ALB、TP、HA、LN、TG 和 CHO 水平升高，呈剂量依赖性恢复正常。生化观察结果辅以大鼠肝组织切片的组织病理学检查。同时，银杏叶多聚戊烯还能显著、剂量依赖性地逆转 CCl（4）降低的抗氧化酶活性，并降低 CCl（4）升高的 MDA 水平。总的来说，银杏叶多聚戊烯的作用与标准药物易善复没有显著差异。
