Zlatkina A R, Belousova E A, Vinitsky L I, Avtandilov G G, Chervonnaya L V
Moscow Regional Clinical Research Institute, U.S.S.R.
Scand J Gastroenterol. 1990 Apr;25(4):341-4. doi: 10.3109/00365529009095496.
The concentrations of cyclic nucleotides (CN) were examined in rectal mucosal biopsy specimens from 52 patients with active ulcerative colitis (UC) and 10 healthy controls. The three degrees of inflammation, evaluated macroscopically by endoscopy and by morphometry in the specimens by estimating the cellular infiltration of the lamina propria, corresponded nicely with each other. The proliferative-regenerative morphologic changes in the rectal mucosa were graded qualitatively and quantitatively in three groups in accordance with defined criteria. A significant difference in cAMP concentration was only found between the most severe degree of inflammation (infiltration, 44.6%) in UC and healthy controls. cAMP concentration in rectal mucosal specimens was lower at the highest degree of regeneration than in specimens with lower degrees. Thus cAMP may play a role in the epithelial regeneration of rectal mucosa. The values of CN concentration did not correlate with the degree of inflammation in rectal mucosa from patients with UC.
检测了52例活动期溃疡性结肠炎（UC）患者及10例健康对照者直肠黏膜活检标本中环核苷酸（CN）的浓度。通过内镜宏观评估以及通过估计固有层细胞浸润对标本进行形态计量学评估的三种炎症程度彼此吻合良好。根据既定标准，将直肠黏膜的增殖-再生形态学变化定性和定量分为三组。仅在UC最严重炎症程度（浸润，44.6%）与健康对照之间发现cAMP浓度存在显著差异。直肠黏膜标本中cAMP浓度在再生程度最高时低于再生程度较低的标本。因此，cAMP可能在直肠黏膜上皮再生中起作用。UC患者直肠黏膜中CN浓度值与炎症程度无关。
