Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA.
J Magn Reson. 2011 Aug;211(2):109-13. doi: 10.1016/j.jmr.2011.04.007. Epub 2011 May 1.
A new method was developed for simultaneous spatial localization and spectral separation of multiple compounds based on a single echo, by designing the acquisition to place individual compounds in separate frequency encoding bands. This method was specially designed for rapid and robust metabolic imaging of hyperpolarized (13)C substrates and their metabolic products, and was investigated in phantom studies and studies in normal mice and transgenic models of prostate cancer to provide rapid metabolic imaging of hyperpolarized [1-(13)C]pyruvate and its metabolic products [1-(13)C]lactate and [1-(13)C]alanine at spatial resolutions up to 3mm in-plane. Elevated pyruvate and lactate signals in the vicinity of prostatic tissues were observed in transgenic tumor mice. The multi-band frequency encoding technique enabled rapid metabolic imaging of hyperpolarized (13)C compounds with important advantages over prior approaches, including less complicated acquisition and reconstruction methods.
一种新方法基于单个回波，通过设计采集使单个化合物处于不同的频率编码带，实现了对多种化合物的同时空间定位和光谱分离。该方法专门设计用于快速和稳健的极化（13）C 底物及其代谢产物的代谢成像，在幻影研究以及正常小鼠和前列腺癌转基因模型的研究中进行了研究，以提供高达 3mm 平面内空间分辨率的极化 [1-（13）C]丙酮酸及其代谢产物 [1-（13）C]乳酸和 [1-（13）C]丙氨酸的快速代谢成像。在转基因肿瘤小鼠中，观察到前列腺组织附近的丙酮酸和乳酸信号升高。与先前的方法相比，多频带频率编码技术实现了极化（13）C 化合物的快速代谢成像，具有重要优势，包括更简单的采集和重建方法。
