HIV 和丙型肝炎病毒合并感染患者的 FIB4、肝硬度与代谢参数之间的相关性。
Correlation between FIB4, liver stiffness and metabolic parameters in patients with HIV and hepatitis C virus co-infection.
机构信息
Division of Infectious and Tropical Diseases, Foundation IRCCS San Matteo Hospital, University of Pavia, Pavia, Italy.
出版信息
Dig Liver Dis. 2011 Jul;43(7):575-8. doi: 10.1016/j.dld.2011.03.009. Epub 2011 May 19.
BACKGROUND/AIMS: Assessment of liver fibrosis is crucial in HIV/HCV coinfected patients, in whom metabolic disturbances are frequent. Aims of this study were to analyse the association of two non-invasive liver fibrosis evaluation methods, liver stiffness measurement and FIB4, and their correlation with metabolic parameters.
METHODS
This was a single centre cross-sectional study. All patients underwent biochemical and virological assessment, FIB4 score, HOMA and transient elastography.
RESULTS
Seventy-five patients were evaluated. Liver stiffness values positively correlated with FIB4 (R = 0.62; p < 0.0001). By ROC curve analysis the optimal cut-off for liver stiffness to identify high FIB4 was calculated as 10.1 kPa. The area under the ROC curve was 0.78 (95% CI 0.78-0.94, sensitivity 83.3%, specificity 80.7%). Liver stiffness values positively correlated with HOMA score (R = 0.31; p = 0.006).
CONCLUSIONS
The combination of two non invasive tools provide a useful system for the assessment of fibrosis evolution in patients with HIV-HCV coinfection.
背景/目的：在 HIV/HCV 合并感染患者中，评估肝纤维化至关重要，因为此类患者常伴有代谢紊乱。本研究旨在分析两种非侵入性肝纤维化评估方法（肝硬度测量和 FIB4）的相关性，并分析其与代谢参数的相关性。
方法
这是一项单中心横断面研究。所有患者均接受了生化和病毒学评估、FIB4 评分、HOMA 和瞬时弹性成像检查。
结果
共评估了 75 例患者。肝硬度值与 FIB4 呈正相关（R = 0.62；p < 0.0001）。通过 ROC 曲线分析，计算出肝硬度识别高 FIB4 的最佳截断值为 10.1kPa。ROC 曲线下面积为 0.78（95%CI 0.78-0.94，敏感性 83.3%，特异性 80.7%）。肝硬度值与 HOMA 评分呈正相关（R = 0.31；p = 0.006）。
结论
两种非侵入性工具的联合使用为评估 HIV-HCV 合并感染患者的纤维化演变提供了一种有用的系统。
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