Hefei National Laboratory for Physical Sciences at Microscale and School of Life Science, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230027, China.
Nucleic Acids Res. 2011 Jul;39(Web Server issue):W139-44. doi: 10.1093/nar/gkr351. Epub 2011 May 19.
MicroRNAs (miRNAs) are critical regulators in the complex cellular networks. The mirAct web server (http://sysbio.ustc.edu.cn/software/mirAct) is a tool designed to investigate miRNA activity based on gene-expression data by using the negative regulation relationship between miRNAs and their target genes. mirAct supports multiple-class data and enables clustering analysis based on computationally determined miRNA activity. Here, we describe the framework of mirAct, demonstrate its performance by comparing with other similar programs and exemplify its applications using case studies.
MicroRNAs (miRNAs) 是细胞网络中关键的调控因子。mirAct 网络服务器（http://sysbio.ustc.edu.cn/software/mirAct）是一款基于基因表达数据，利用 miRNA 与其靶基因之间的负调控关系来研究 miRNA 活性的工具。mirAct 支持多类别数据，并能够基于计算确定的 miRNA 活性进行聚类分析。在这里，我们描述了 mirAct 的框架，通过与其他类似程序进行比较来展示其性能，并通过案例研究来举例说明其应用。
