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DIANA miRPath v.2.0：研究 miRNA 在通路中的组合效应。

DIANA miRPath v.2.0: investigating the combinatorial effect of microRNAs in pathways.

机构信息

DIANA-Lab, Institute of Molecular Oncology, Biomedical Sciences Research Center 'Alexander Fleming', 16672 Vari, Greece.

出版信息

Nucleic Acids Res. 2012 Jul;40(Web Server issue):W498-504. doi: 10.1093/nar/gks494. Epub 2012 May 30.

DOI:10.1093/nar/gks494
PMID:22649059
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3394305/
Abstract

MicroRNAs (miRNAs) are key regulators of diverse biological processes and their functional analysis has been deemed central in many research pipelines. The new version of DIANA-miRPath web server was redesigned from the ground-up. The user of DNA Intelligent Analysis (DIANA) DIANA-miRPath v2.0 can now utilize miRNA targets predicted with high accuracy based on DIANA-microT-CDS and/or experimentally verified targets from TarBase v6; combine results with merging and meta-analysis algorithms; perform hierarchical clustering of miRNAs and pathways based on their interaction levels; as well as elaborate sophisticated visualizations, such as dendrograms or miRNA versus pathway heat maps, from an intuitive and easy to use web interface. New modules enable DIANA-miRPath server to provide information regarding pathogenic single nucleotide polymorphisms (SNPs) in miRNA target sites (SNPs module) or to annotate all the predicted and experimentally validated miRNA targets in a selected molecular pathway (Reverse Search module). DIANA-miRPath v2.0 is an efficient and yet easy to use tool that can be incorporated successfully into miRNA-related analysis pipelines. It provides for the first time a series of highly specific tools for miRNA-targeted pathway analysis via a web interface and can be accessed at http://www.microrna.gr/miRPathv2.

摘要

微 RNA（miRNAs）是多种生物过程的关键调节因子，其功能分析被认为是许多研究管道的核心。DIANA-miRPath 网络服务器的新版本是从头开始重新设计的。现在，使用 DNA 智能分析（DIANA）DIANA-miRPath v2.0 的用户可以利用基于 DIANA-microT-CDS 准确预测的 miRNA 靶标和/或来自 TarBase v6 的实验验证靶标；通过合并和荟萃分析算法组合结果；根据其相互作用水平对 miRNA 和途径进行层次聚类；以及从直观易用的网络界面详细呈现复杂的可视化效果，如 dendrograms 或 miRNA 与途径热图。新模块使 DIANA-miRPath 服务器能够提供 miRNA 靶位中致病性单核苷酸多态性（SNP）的信息（SNP 模块），或注释所选分子途径中所有预测和实验验证的 miRNA 靶标（反向搜索模块）。DIANA-miRPath v2.0 是一种高效且易于使用的工具，可以成功地集成到 miRNA 相关分析管道中。它通过网络界面首次提供了一系列用于 miRNA 靶向途径分析的高度特定工具，可在 http://www.microrna.gr/miRPathv2 上访问。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afc5/3394305/44183fc5bda9/gks494f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afc5/3394305/0c85e7ba6708/gks494f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afc5/3394305/58d00b25a8cf/gks494f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afc5/3394305/44183fc5bda9/gks494f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afc5/3394305/0c85e7ba6708/gks494f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afc5/3394305/58d00b25a8cf/gks494f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afc5/3394305/44183fc5bda9/gks494f3.jpg

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