Mirin：在蛋白质-蛋白质相互作用网络中识别微小RNA调控模块

Mirin: identifying microRNA regulatory modules in protein-protein interaction networks.

作者信息

Yang Ken-Chi, Hsu Chia-Lang, Lin Chen-Ching, Juan Hsueh-Fen, Huang Hsuan-Cheng

机构信息

Institute of Biomedical Informatics, Center for Systems and Synthetic Biology, National Yang-Ming University, Taipei 112, Department of Life Science, Graduate Institute of Biomedical Electronics and Bioinformatics and Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan Institute of Biomedical Informatics, Center for Systems and Synthetic Biology, National Yang-Ming University, Taipei 112, Department of Life Science, Graduate Institute of Biomedical Electronics and Bioinformatics and Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan.

出版信息

Bioinformatics. 2014 Sep 1;30(17):2527-8. doi: 10.1093/bioinformatics/btu306. Epub 2014 May 2.

DOI:10.1093/bioinformatics/btu306

PMID:24794934

Abstract

UNLABELLED

Exploring microRNA (miRNA) regulations and protein-protein interactions could reveal the molecular mechanisms responsible for complex biological processes. Mirin is a web-based application suitable for identifying functional modules from protein-protein interaction networks regulated by aberrant miRNAs under user-defined biological conditions such as cancers. The analysis involves combining miRNA regulations, protein-protein interactions between target genes, as well as mRNA and miRNA expression profiles provided by users. Mirin has successfully uncovered oncomirs and their regulatory networks in various cancers, such as gastric and breast cancer.

AVAILABILITY AND IMPLEMENTATION

Mirin is freely available at http://mirin.ym.edu.tw/.

SUPPLEMENTARY INFORMATION

Supplementary data are available at Bioinformatics online.

摘要

未标注

探索微小RNA（miRNA）调控和蛋白质-蛋白质相互作用可以揭示负责复杂生物过程的分子机制。Mirin是一个基于网络的应用程序，适用于在用户定义的生物学条件（如癌症）下，从由异常miRNA调控的蛋白质-蛋白质相互作用网络中识别功能模块。该分析涉及结合miRNA调控、靶基因之间的蛋白质-蛋白质相互作用以及用户提供的mRNA和miRNA表达谱。Mirin已成功在各种癌症（如胃癌和乳腺癌）中发现了致癌miRNA及其调控网络。