Department of Internal Medicine, Division of Medicine/Psychiatry, Springfield, IL 62729.
Psychosom Med. 2011 Jun;73(5):407-14. doi: 10.1097/PSY.0b013e31821a196f. Epub 2011 May 19.
To review the literature regarding the role of leptin in psychiatric disorders.
A PubMed search was undertaken using the following keywords: leptin, psychosis, affective disorders, alcohol, psychiatry, depression, dementia, and eating disorders. The articles were restricted to the English language.
The role of leptin in psychiatric populations has been the subject of increasing investigation. Basic science and clinical observations support a role for leptin in mediating cognition and reward processes. The role of leptin in psychiatric illnesses characterized by cognitive deficits has gained increased attention in recent years. Leptin deficiency and resistance have also been associated with eating disorders as well as affective, alcohol dependence, and psychotic disorders. The mechanisms underlining these associations remain to be determined.
Clinical research suggests an important role of leptin in psychiatric illnesses. Given the morbidity associated with mental illness, clinical research on the role of leptin and related novel therapeutic modalities is needed.
综述瘦素在精神疾病中的作用。
使用以下关键词在 PubMed 上进行检索：瘦素、精神病、情感障碍、酒精、精神病学、抑郁、痴呆和饮食障碍。文章仅限于英语。
瘦素在精神人群中的作用一直是越来越多的研究课题。基础科学和临床观察支持瘦素在调节认知和奖励过程中的作用。近年来，瘦素在以认知缺陷为特征的精神疾病中的作用引起了越来越多的关注。瘦素缺乏和抵抗也与饮食障碍以及情感、酒精依赖和精神病性障碍有关。这些关联的机制仍有待确定。
临床研究表明瘦素在精神疾病中起着重要作用。鉴于与精神疾病相关的发病率，需要对瘦素和相关新型治疗方式的作用进行临床研究。
