嗜碱性粒细胞、IgE 和抗体介导的肾脏疾病。
Basophils, IgE, and autoantibody-mediated kidney disease.
机构信息
Department of Internal Medicine, Hospital Clinic, Institut d'Investigacions Bimoèdiques August Pi i Sunyer, University of Barcelona, 08036 Barcelona, Spain.
出版信息
J Immunol. 2011 Jun 1;186(11):6083-90. doi: 10.4049/jimmunol.1002648.
Abstract
Basophils are of interest in immunology due to their ability to produce a Th2-signature cytokine, IL-4, following activation. A new understanding of the role of basophils in immunity shows novel functions at a cellular level through which basophils influence adaptive immunity. This review summarizes new advances in basophil biology and discusses new roles for basophils in human disease, especially in the mediation of the pathogenesis of lupus nephritis. Recently, basophils have been shown to contribute to self-reactive Ab production in systemic lupus erythematosus and may enhance pre-existing loss of B cell tolerance, suggesting that basophils, IL-4, and IgE mediate the pathogenesis of lupus nephritis by promoting the Th2 environment and activating autoreactive B cells. In addition to envisaging exciting therapeutic prospects, these novel findings open the way for the study of basophils in other autoimmune and renal diseases.
摘要
由于其在活化后能够产生 Th2 特征细胞因子 IL-4，嗜碱性粒细胞在免疫学中备受关注。通过细胞水平上的新理解，嗜碱性粒细胞在适应性免疫中的作用显示出了新的功能。本文综述了嗜碱性粒细胞生物学的新进展，并讨论了嗜碱性粒细胞在人类疾病中的新作用，特别是在介导狼疮肾炎发病机制中的作用。最近的研究表明，嗜碱性粒细胞有助于全身性红斑狼疮中的自身反应性 Ab 产生，并可能增强已存在的 B 细胞耐受丧失，这表明嗜碱性粒细胞、IL-4 和 IgE 通过促进 Th2 环境和激活自身反应性 B 细胞，介导狼疮肾炎的发病机制。除了设想令人兴奋的治疗前景外，这些新发现还为研究其他自身免疫性和肾脏疾病中的嗜碱性粒细胞开辟了道路。
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