Division of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine and Greenebaum Cancer Center, Baltimore, Maryland 21201, USA.
Curr Opin Gastroenterol. 2011 Jul;27(4):363-7. doi: 10.1097/MOG.0b013e328347bae8.
To summarize the recent literature on endoscopic spray cryotherapy for the treatment of Barrett's esophagus and esophageal cancer.
Endoscopic spray cryotherapy is a relatively new ablative modality for the treatment of gastrointestinal diseases. Spray cryotherapy rapidly cools tissues by spraying them with either liquid nitrogen or rapidly expanding carbon dioxide gas. Initial, nonrandomized and uncontrolled studies show success rates comparable to other ablative modalities for the treatment of Barrett's esophagus with high-grade dysplasia, with complete eradication of dysplasia seen in 87-96% and complete eradication of intestinal metaplasia in 57-96% of treated patients. In early-stage esophageal cancer, spray cryotherapy appears to have a unique role, eliminating mucosal cancer in 75% of patients, including those who have failed other modalities. Patient tolerance of the procedure is very good. Limitations of current studies include small sample sizes and short durations of follow-up, and further studies are needed to validate the promising early results.
Endoscopic spray cryotherapy is a promising ablative modality for treatment of Barrett's esophagus and esophageal cancer.
总结内镜喷雾冷冻治疗 Barrett 食管和食管癌的最新文献。
内镜喷雾冷冻治疗是一种治疗胃肠道疾病的相对较新的消融方式。喷雾冷冻治疗通过向组织喷洒液氮或迅速膨胀的二氧化碳气体，使组织迅速冷却。初步的非随机和非对照研究显示，其治疗 Barrett 食管高级别异型增生的成功率可与其他消融方式相媲美，在 87%至 96%的治疗患者中可完全消除异型增生，在 57%至 96%的治疗患者中可完全消除肠化生。在早期食管癌中，喷雾冷冻治疗似乎具有独特的作用，可消除 75%的黏膜癌患者，包括那些经其他方式治疗失败的患者。患者对该治疗方法的耐受性非常好。目前研究的局限性包括样本量小和随访时间短，需要进一步的研究来验证早期有前景的结果。
内镜喷雾冷冻治疗是治疗 Barrett 食管和食管癌的一种很有前途的消融方式。
