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Human papillomavirus type-16 DNA integration in nuclear matrix and chromosome scaffold associated DNA in a cervical-carcinoma cell-line.

作者信息

Yam Y, Chew E, Yang L, Chengchew S, Ding M

机构信息

CHINESE UNIV HONG KONG,DEPT ANAT,SHA TIN,HONG KONG. CHINESE UNIV HONG KONG,DEPT PHYSIOL,SHA TIN,HONG KONG. BEIJING UNIV,DEPT CELL BIOL,BEIJING,PEOPLES R CHINA.

出版信息

Oncol Rep. 1995 Nov;2(6):1093-6. doi: 10.3892/or.2.6.1093.

DOI:10.3892/or.2.6.1093
PMID:21597860
Abstract

MARs (matrix attachment region) and SARs (scaffold attachment region) are fragments of DNA that associated with nuclear matrix and chromosome scaffold even after extensive removal of most of the nuclear proteins and chromatin. The present study showed the association of human papillomavirus type 16 DNA with these fragments by polymerase chain reaction in a cervical carcinoma cell line, CC3/CUHK3. This finding proposed an alternative evidence for the elevated transcription rate of the viral genome in transformed cells as nuclear matrix has been proposed to be sites of DNA replication and transcription.

摘要

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