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Human papillomavirus 16 E6 is associated with the nuclear matrix of esophageal carcinoma cells.人乳头瘤病毒16 E6与食管癌细胞的核基质相关。
World J Gastroenterol. 2001 Dec;7(6):788-91. doi: 10.3748/wjg.v7.i6.788.
2
Preferential nuclear localization of the human papillomavirus type 16 E6 oncoprotein in cervical carcinoma cells.人乳头瘤病毒16型E6癌蛋白在宫颈癌细胞中的核内优先定位。
J Gen Virol. 2003 Aug;84(Pt 8):2099-2104. doi: 10.1099/vir.0.18961-0.
3
Up-regulation of FOXM1 by E6 oncoprotein through the MZF1/NKX2-1 axis is required for human papillomavirus-associated tumorigenesis.E6癌蛋白通过MZF1/NKX2-1轴上调FOXM1是人类乳头瘤病毒相关肿瘤发生所必需的。
Neoplasia. 2014 Nov 20;16(11):961-71. doi: 10.1016/j.neo.2014.09.010. eCollection 2014 Nov.
4
Immunohistochemical co-expression of human papillomavirus type 16/18 transforming (E6) oncoprotein and p53 tumour suppressor gene proteins in oesophageal cancer.人乳头瘤病毒16/18型转化（E6）癌蛋白与p53肿瘤抑制基因蛋白在食管癌中的免疫组织化学共表达
Indian J Exp Biol. 1998 Jun;36(6):559-63.
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Human papillomavirus promotes esophageal squamous cell carcinoma by regulating DNA methylation and expression of HLA-DQB1.人乳头瘤病毒通过调节DNA甲基化和HLA-DQB1的表达促进食管鳞状细胞癌。
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Relationship between HPV16/18 E6 and 53, 21WAF1, MDM2, Ki67 and cyclin D1 expression in esophageal squamous cell carcinoma: comparative study by using tissue microarray technology.人乳头瘤病毒16/18 E6与食管鳞状细胞癌中53、21WAF1、MDM2、Ki67及细胞周期蛋白D1表达的关系：应用组织芯片技术的比较研究
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7
Human papillomavirus (HPV) oncoprotein E6 facilitates Calcineurin-Nuclear factor for activated T cells 2 (NFAT2) signaling to promote cellular proliferation in cervical cell carcinoma.人乳头瘤病毒（HPV）癌蛋白 E6 促进钙调神经磷酸酶-激活 T 细胞核因子 2（NFAT2）信号通路，促进宫颈癌的细胞增殖。
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[Detection of HPV in human esophageal cancer in high-incidence area and its correlation with p53 expression].
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Association of p53 codon 72 genotypes and clinical outcome in human papillomavirus-infected lung cancer patients.p53 密码子 72 基因型与 HPV 感染肺癌患者临床结局的相关性。
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Subcellular localization and quantitation of the human papillomavirus type 16 E6 oncoprotein through immunocytochemistry detection.通过免疫细胞化学检测定位和定量人乳头瘤病毒 16 型 E6 癌蛋白。
Virology. 2013 Jan 20;435(2):425-32. doi: 10.1016/j.virol.2012.09.032. Epub 2012 Oct 18.

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Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos.通过高通量分析 DNA 晕环揭示的转化诱导的 DNA-核基质界面变化。
Sci Rep. 2017 Jul 25;7(1):6475. doi: 10.1038/s41598-017-06459-7.
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Phase-contrast X-ray CT imaging of esophagus and esophageal carcinoma.食管及食管癌的相衬X线计算机断层成像
Sci Rep. 2014 Jun 18;4:5332. doi: 10.1038/srep05332.
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Integration of human papillomavirus 18 DNA in esophageal carcinoma 109 cells.人乳头瘤病毒 18 型 DNA 在食管癌细胞 109 中的整合。
World J Gastroenterol. 2011 Oct 7;17(37):4242-6. doi: 10.3748/wjg.v17.i37.4242.
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Human papillomavirus in squamous cell carcinoma of esophagus in a high-risk population.高危人群食管鳞状细胞癌中的人乳头瘤病毒
World J Gastroenterol. 2005 Feb 28;11(8):1200-3. doi: 10.3748/wjg.v11.i8.1200.
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Comparison of nuclear matrix proteins between gastric cancer and normal gastric tissue.胃癌组织与正常胃组织中核基质蛋白的比较。
World J Gastroenterol. 2004 Jun 15;10(12):1819-21. doi: 10.3748/wjg.v10.i12.1819.
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Separation and identification of differentially expressed nuclear matrix proteins between human esophageal immortalized and carcinomatous cell lines.人食管永生化细胞系和癌细胞系之间差异表达的核基质蛋白的分离与鉴定
World J Gastroenterol. 2003 Oct;9(10):2143-8. doi: 10.3748/wjg.v9.i10.2143.
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Detection of human papillomavirus in Chinese esophageal squamous cell carcinoma and its adjacent normal epithelium.中国食管鳞状细胞癌及其癌旁正常上皮中人乳头瘤病毒的检测
World J Gastroenterol. 2003 Jun;9(6):1170-3. doi: 10.3748/wjg.v9.i6.1170.
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Preoperative TN staging of esophageal cancer: comparison of miniprobe ultrasonography, spiral CT and MRI.食管癌术前TN分期：微型探头超声检查、螺旋CT与MRI的比较
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Identification of differentially expressed proteins between human esophageal immortalized and carcinomatous cell lines by two-dimensional electrophoresis and MALDI-TOF-mass spectrometry.通过二维电泳和基质辅助激光解吸电离飞行时间质谱法鉴定人食管永生化细胞系和癌细胞系之间的差异表达蛋白质
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Human papillomavirus type-16 DNA integration in nuclear matrix and chromosome scaffold associated DNA in a cervical-carcinoma cell-line.
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Human papillomavirus 16 E6 and E7 are associated with the nuclear matrix of cervical carcinoma cells.
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Function of apoptosis and expression of the proteins Bcl-2, p53 and C-myc in the development of gastric cancer.细胞凋亡功能及Bcl-2、p53和C-myc蛋白在胃癌发生发展中的表达
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Infrequent p53 gene mutation and expression of the cardia adenocarcinomas from a high-incidence area of Southwest China.中国西南部高发病区贲门腺癌中p53基因的罕见突变与表达
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Immunohistochemical study on p53, H-rasp21, c-erbB-2 protein and PCNA expression in HCC tissues of Han and minority ethnic patients.汉族及少数民族肝癌患者癌组织中p53、H-rasp21、c-erbB-2蛋白及PCNA表达的免疫组化研究
World J Gastroenterol. 2000 Apr;6(2):234-238. doi: 10.3748/wjg.v6.i2.234.
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Effect of retinoic acid on the changes of nuclear matrix in termediate filament system in gastric carcinoma cells.维甲酸对胃癌细胞中间丝系统核基质变化的影响。
World J Gastroenterol. 1999 Oct;5(5):417-420. doi: 10.3748/wjg.v5.i5.417.
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Overexpression of P53 and its risk factors in esophageal cancer in urban areas of Xi'an.西安市区食管癌中P53的过表达及其危险因素
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8
Human papillomavirus type 16 is an important infectious factor in the high incidence of esophageal cancer in Anyang area of China.人乳头瘤病毒16型是中国安阳地区食管癌高发的重要感染因素。
Carcinogenesis. 2001 Jun;22(6):929-34. doi: 10.1093/carcin/22.6.929.
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Evaluation of HPV, CMV, HSV and EBV in esophageal squamous cell carcinomas from a high-incidence area of China.中国高发地区食管鳞状细胞癌中HPV、CMV、HSV和EBV的评估
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Delaying S-phase progression rescues cells from heat-induced S-phase hypertoxicity.延迟S期进程可使细胞从热诱导的S期高毒性中恢复。
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人乳头瘤病毒16 E6与食管癌细胞的核基质相关。

Human papillomavirus 16 E6 is associated with the nuclear matrix of esophageal carcinoma cells.

作者信息

Chen H B, Chen L, Zhang J K, Shen Z Y, Su Z J, Cheng S B, Chew E C

机构信息

Department of Histology and Embryology, Shantou University Medical College, Guangdong Province, China.

出版信息

World J Gastroenterol. 2001 Dec;7(6):788-91. doi: 10.3748/wjg.v7.i6.788.

DOI:10.3748/wjg.v7.i6.788
PMID:11854902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4695595/
Abstract

AIM

To explore the etiologic role of HPV infection in esophageal carcinoma, and the association of HPV-16 E6 with the nuclear matrix of carcinoma cells.

METHODS

Two esophageal carcinoma cell lines,EC/CUHK1 and EC/CUHK2, were tested for HPV-16 E6 subgenetic fragment by polymerase chain reaction amplification of virus DNA associated nuclear matrix. RT-PCR and immunocytochemistry were also used to visualize the expression of E6 subgene in the cells.

RESULTS

The HPV-16 E6 subgenetic fragment was found to be present in nuclear matrix-associated DNA, E6 oncoprotein localized in the nucleus where it is tightly associated with nuclear matrix after sequential extraction in EC/CUHK2 cells. It was not detected, however, in EC/CUHK1 cells.

CONCLUSION

The interaction between HPV-16 E6 and nuclear matrix may contribute to the virus induced carcinogenesis in esophageal carcinoma.

摘要

目的

探讨人乳头瘤病毒（HPV）感染在食管癌发病中的作用，以及HPV-16 E6与癌细胞核基质的关系。

方法

采用聚合酶链反应扩增与核基质相关的病毒DNA，检测两种食管癌细胞系EC/CUHK1和EC/CUHK2中的HPV-16 E6亚基因片段。同时运用逆转录聚合酶链反应（RT-PCR）和免疫细胞化学方法观察细胞中E6亚基因的表达情况。

结果

在EC/CUHK2细胞中，经连续抽提后发现HPV-16 E6亚基因片段存在于与核基质相关的DNA中，E6癌蛋白定位于细胞核内，并与核基质紧密结合；而在EC/CUHK1细胞中未检测到。

结论

HPV-16 E6与核基质之间的相互作用可能在食管癌病毒诱导的致癌过程中发挥作用。