Ishii Y, Tanizawa H, Takino Y
School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Chem Pharm Bull (Tokyo). 1990 Jan;38(1):197-200. doi: 10.1248/cpb.38.197.
The mechanism of action of aloe-emodin-9-anthrone, a decomposition product of barbaloin, in causing a significant increase in the water content of the rat large intestine, was investigated. Aloe-emodin-9-anthrone inhibited rat colonic Na+, K(+)-adenosine triphosphatase (ATPase) in vitro, and increased the paracellular permeability across the rat colonic mucosa in vivo. Therefore, it seemed that the increase in water content of the rat large intestine produced by aloe-emodin-9-anthrone was due to both inhibition of absorption and stimulation of secretion without stimulation of peristalsis. Furthermore, pretreatment with loperamide, an antidiarrheal agent, completely prevented the increase of paracellular permeability induced by aloe-emodin-9-anthrone but did not completely reduce the concomitant increase in residual fluid volume. These findings suggest that aloe-emodin-9-anthrone has multiple mechanisms of action involved in the increase of water content in the rat large intestine.
研究了芦荟苷的分解产物芦荟大黄素 - 9 - 蒽酮使大鼠大肠含水量显著增加的作用机制。芦荟大黄素 - 9 - 蒽酮在体外抑制大鼠结肠Na⁺、K⁺ - 腺苷三磷酸酶（ATP酶），并在体内增加大鼠结肠黏膜的细胞旁通透性。因此，芦荟大黄素 - 9 - 蒽酮引起的大鼠大肠含水量增加似乎是由于吸收抑制和分泌刺激，而未刺激蠕动。此外，用止泻药洛哌丁胺预处理可完全阻止芦荟大黄素 - 9 - 蒽酮诱导的细胞旁通透性增加，但并未完全减少伴随的残留液体量增加。这些发现表明，芦荟大黄素 - 9 - 蒽酮在大鼠大肠含水量增加中涉及多种作用机制。
