Ishii Y, Takino Y, Toyo'oka T, Tanizawa H
School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Biol Pharm Bull. 1998 Nov;21(11):1226-7. doi: 10.1248/bpb.21.1226.
The cathartic effect of isobarbaloin, a stereoisomer of barbaloin (compound principally responsible for the cathartic activity of Aloe), was examined in male rats by oral administration. Individual differences in sensitivity in the laxative activity of isobarbaloin and barbaloin was not found. The cathartic activity (ED50) of isobarbaloin in barbaloin positive rats was 19.2 mg/kg, nearly equal to that of barbaloin (19.5 mg/kg). Also, isobarbaloin administered orally was demonstrated to decompose to aloe-emodin-9-anthrone (active metabolite of barbaloin) as well as to barbaloin. Therefore, it is considered that the mechanism underlying the cathartic effect of isobarbaloin is the same as that of barbaloin.
通过口服给药，在雄性大鼠中研究了异芦荟苷（芦荟苷的立体异构体，芦荟苷是主要负责芦荟泻下活性的化合物）的泻下作用。未发现异芦荟苷和芦荟苷在泻下活性方面的敏感性存在个体差异。在芦荟苷阳性大鼠中，异芦荟苷的泻下活性（半数有效剂量）为19.2毫克/千克，几乎与芦荟苷（19.5毫克/千克）相同。此外，口服给药的异芦荟苷被证明会分解为芦荟大黄素-9-蒽酮（芦荟苷的活性代谢物）以及芦荟苷。因此，认为异芦荟苷泻下作用的潜在机制与芦荟苷相同。
