Wang Ying, Zhu Jingbo, Fu Shaoping, Zhu Linmin, Zhang Yi
School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.
Zhongguo Zhong Yao Za Zhi. 2011 Feb;36(4):434-8.
To study the chemical changes of salvianolic acid B and lithospermic acid of Salvia miltiorrhiza under the conditions of high temperature and high pressure and explore the reaction mechanism.
S. miltiorrhiza extracts, salvianolic acid B and lithospermic acid were put in the reactor under the conditions of high temperature and high pressure (120 degrees C, 0.2 MPa), and the chemical changes and stability was studied.
Salvianolic acid A was the primary product in salvianolic acid B and lithospermic acid's conversion process, and lithospermic acid was an intermediate in the conversion process of salvianolic acid B. Compared with salvianolic acid B, lithospermic acid could convert into more salvianolic acid A and fewer other products in the same conditions. Salvianolic acid A was not stable under the conditions of high temperature and high pressure, and could sequentially convert into other small molecules.
Referring to the chemical conversion of salvianolic acid B and lithospermic acid, a method of large-scale preparation of salvianolic acid A can be developed.
研究高温高压条件下丹参中丹酚酸B和紫草酸的化学变化，并探讨其反应机理。
将丹参提取物、丹酚酸B和紫草酸置于高温高压（120℃，0.2MPa）条件下的反应器中，研究其化学变化及稳定性。
丹酚酸A是丹酚酸B和紫草酸转化过程中的主要产物，紫草酸是丹酚酸B转化过程中的中间体。与丹酚酸B相比，紫草酸在相同条件下能转化生成更多的丹酚酸A和更少的其他产物。丹酚酸A在高温高压条件下不稳定，可依次转化为其他小分子。
参照丹酚酸B和紫草酸的化学转化，可开发一种大规模制备丹酚酸A的方法。
