Department of National Products Chemistry, Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, PR China.
Department of National Products Chemistry, Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, PR China.
Phytomedicine. 2014 May 15;21(6):906-11. doi: 10.1016/j.phymed.2014.01.005. Epub 2014 Feb 16.
Salvianolic acid A (Sal A), an important constituent of Radix Salviae Miltiorrhizae (RSM), is effective for the treatment of myocardial infarction (MI) and coronary heart disease due to its potential in the improvement of acute myocardial ischemia. However, its content is very low in RSM. So it is obvious to find a rich source of Sal A or to improve its content by conversion of other related components into Sal A modifying reaction conditions. In this research we focused on the conversion of Sal B into Sal A in aqueous solutions of RSM by using different reaction conditions including pH, temperature, pressure and humidity. During the reactions, the contents of Sal A, Sal B and danshensu in the RSM were analyzed by high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LCMS). The results indicated that the conversion of Sal B into Sal A in RSM tissues under the conditions of a high temperature, high pressure and high humidity was efficient and thereby, was readily utilized to prepare rich Sal A materials in practice.
丹酚酸 A（Sal A）是丹参的重要成分，由于其在改善急性心肌缺血方面的潜力，可有效治疗心肌梗死（MI）和冠心病。然而，它在丹参中的含量非常低。因此，寻找 Sal A 的丰富来源或通过将其他相关成分转化为 Sal A 来提高其含量的修饰反应条件是显而易见的。在这项研究中，我们专注于在丹参的水溶液中，通过不同的反应条件（包括 pH 值、温度、压力和湿度）将丹酚酸 B 转化为丹酚酸 A。在反应过程中，通过高效液相色谱（HPLC）和液相色谱-质谱（LCMS）分析了丹酚酸 A、丹酚酸 B 和丹参素在丹参中的含量。结果表明，在高温、高压和高湿度的条件下，丹酚酸 B 在丹参组织中转化为丹酚酸 A 的效率很高，因此，在实践中很容易用于制备富含丹酚酸 A 的材料。
