无机磷酸盐和核苷酸磷酸盐对肾上腺皮质铁氧化还原蛋白-肾上腺皮质铁氧化还原蛋白还原酶系统电子转移的速率增强作用。
Rate enhancement of the electron transfer of the adrenodoxin-adrenodoxin reductase system by inorganic and nucleotide phosphates.
作者信息
Yamano T, Nonaka Y, Miura R
机构信息
Laboratory of Chemistry, Kansai Medical University, Hirakata, Japan.
出版信息
FEBS Lett. 1990 May 7;264(1):138-40. doi: 10.1016/0014-5793(90)80784-g.
Phosphate and pyrophosphate increased the rate of reduction of adrenodoxin by NADPH-adrenodoxin reductase and NADPH, pyrophosphate being one order more effective than the former. However, the cytochrome c reduction by the electron transport system was inhibited in the presence of inorganic (pyro)phosphate. On the other hand, ADP and ATP enhanced the rates of reduction of both adrenodoxin and cytochrome c through adrenodoxin by the electron transport system. GTP also enhanced the rate of reduction of cytochrome c by this system, whereas AMP showed no appreciable enhancement. These inorganic and nucleotide phosphates did not affect the rate of ferricyanide reduction by the reductase.
磷酸盐和焦磷酸盐可提高NADPH-肾上腺皮质铁氧化还原蛋白还原酶与NADPH对肾上腺皮质铁氧化还原蛋白的还原速率，焦磷酸盐的效果比前者高一个数量级。然而，在无机（焦）磷酸盐存在的情况下，电子传递系统对细胞色素c的还原作用受到抑制。另一方面，ADP和ATP可提高电子传递系统通过肾上腺皮质铁氧化还原蛋白对肾上腺皮质铁氧化还原蛋白和细胞色素c的还原速率。GTP也可提高该系统对细胞色素c的还原速率，而AMP则未表现出明显的促进作用。这些无机磷酸盐和核苷酸磷酸盐不会影响还原酶对铁氰化物的还原速率。
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