Program in Prevention and Population Sciences, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, 6701 Rockledge Drive, Suite 10018, Bethesda, MD 20982-7936, USA.
University of Mississippi Medical Center, Jackson, MS, Jackson, MS, USA.
J Clin Lipidol. 2011 May-Jun;5(3):173-178. doi: 10.1016/j.jacl.2011.02.002. Epub 2011 Mar 2.
African Americans have historically had high high-density lipoprotein cholesterol (HDL-C) compared with other races and ethnicities.
We sought to characterize whether there is a cross-sectional association between age and HDL-C in a contemporary community-based study of African Americans.
Cross-sectional data were modeled by logistic regression for predictors of HDL-C among African Americans, ages 35-74, participating in the baseline examination of a community-based study of cardiovascular disease in Jackson, Mississippi, during 2000-2004. After excluding persons taking lipid-lowering medications, hormone replacement therapy, oral contraceptives, or thyroid replacement, the analytical data set comprised 2420 persons (1370 women, 1050 men).
HDL-C had a significant positive association with age after controlling for serum triglycerides, sex, waist circumference, percent dietary calories from carbohydrates, alcohol use, and leisure physical activity. Sex was a significant effect modifier of this relationship, whereby the increase in HDL-C with age was steeper for women than for men.
Cross-sectional analysis found a positive association of HDL-C with age while controlling for triglycerides. Careful evaluation of longitudinal data will be needed to confirm whether this is a true effect of aging, or a cohort or survivor effect.
与其他种族和民族相比，非裔美国人的高密度脂蛋白胆固醇（HDL-C）一直较高。
我们试图在一项针对非裔美国人的基于社区的心血管疾病研究的基线检查中，研究年龄与 HDL-C 之间是否存在横断面关联。
采用逻辑回归模型对密西西比州杰克逊市的一项基于社区的心血管疾病研究中 35-74 岁的非裔美国人的 HDL-C 预测因素进行了横断面数据分析。排除服用降脂药物、激素替代疗法、口服避孕药或甲状腺替代药物的患者后，分析数据集包括 2420 人（女性 1370 人，男性 1050 人）。
在控制血清甘油三酯、性别、腰围、碳水化合物热量百分比、饮酒和休闲体力活动后，HDL-C 与年龄呈显著正相关。性别是这种关系的显著效应修饰因子，女性 HDL-C 随年龄的增加比男性更为陡峭。
横断面分析发现，在控制甘油三酯的情况下，HDL-C 与年龄呈正相关。需要仔细评估纵向数据，以确认这是否是衰老的真实影响，还是队列或幸存者效应。
