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基于多分辨率图的组织病理学全切片图像分析:在有丝分裂细胞提取和可视化中的应用。

Multi-resolution graph-based analysis of histopathological whole slide images: application to mitotic cell extraction and visualization.

机构信息

Université de Caen Basse-Normandie, Caen, France.

出版信息

Comput Med Imaging Graph. 2011 Oct-Dec;35(7-8):603-15. doi: 10.1016/j.compmedimag.2011.02.005. Epub 2011 May 19.

DOI:10.1016/j.compmedimag.2011.02.005
PMID:21600733
Abstract

In this paper, we present a graph-based multi-resolution approach for mitosis extraction in breast cancer histological whole slide images. The proposed segmentation uses a multi-resolution approach which reproduces the slide examination done by a pathologist. Each resolution level is analyzed with a focus of attention resulting from a coarser resolution level analysis. At each resolution level, a spatial refinement by label regularization is performed to obtain more accurate segmentation around boundaries. The proposed segmentation is fully unsupervised by using domain specific knowledge.

摘要

在本文中,我们提出了一种基于图的多分辨率方法,用于提取乳腺癌组织学全切片图像中的有丝分裂。所提出的分割使用多分辨率方法,该方法再现了病理学家进行的幻灯片检查。在每个分辨率级别上,都使用来自较粗分辨率级别的分析的关注焦点来进行分析。在每个分辨率级别上,通过标签正则化进行空间细化,以在边界周围获得更准确的分割。通过使用特定于领域的知识,所提出的分割是完全无监督的。

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Multi-resolution graph-based analysis of histopathological whole slide images: application to mitotic cell extraction and visualization.基于多分辨率图的组织病理学全切片图像分析:在有丝分裂细胞提取和可视化中的应用。
Comput Med Imaging Graph. 2011 Oct-Dec;35(7-8):603-15. doi: 10.1016/j.compmedimag.2011.02.005. Epub 2011 May 19.
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