Yamaguchi M, Mori N
Department of Obstetrics and Gynecology, Miyazaki Medical College, Japan.
Prostaglandins Leukot Essent Fatty Acids. 1990 Jan;39(1):43-5. doi: 10.1016/0952-3278(90)90170-p.
In order to investigate whether prostanoids are involved in the pathophysiology of endometriosis, prostaglandin and leukotriene concentrations in peritoneal fluid were measured in adenomyosis, ovarian chocolate cyst and uterine leiomyoma. In the secretory phase, there was no significant difference in 6-keto PGF1 alpha concentration in peritoneal fluid between the adenomyosis group and the leiomyoma group. TXB2 concentration did not significantly differ in the three study groups. Leukotriene C4 level in the adenomyosis group was significantly higher than that of leiomyoma in the secretory phase. Leukotriene B4 could not be detected by our assay system. Our results suggest that leukotriene C4 is possibly involved in the pathophysiology of endometriosis.
为了研究前列腺素是否参与子宫内膜异位症的病理生理过程，我们测定了子宫腺肌病、卵巢巧克力囊肿和子宫肌瘤患者腹腔液中前列腺素和白三烯的浓度。在分泌期，子宫腺肌病组和子宫肌瘤组腹腔液中6-酮-前列腺素F1α浓度无显著差异。三个研究组的血栓素B2浓度无显著差异。在分泌期，子宫腺肌病组白三烯C4水平显著高于子宫肌瘤组。我们的检测系统未检测到白三烯B4。我们的结果表明，白三烯C4可能参与子宫内膜异位症的病理生理过程。
