Service d'oto-rhino-laryngologie et de chirurgie cervicofaciale, CHU d'Angers, 20, rue de Savoie, 49100 Angers, France.
Eur Ann Otorhinolaryngol Head Neck Dis. 2011 Nov;128(5):224-9. doi: 10.1016/j.anorl.2010.12.010. Epub 2011 May 19.
To evaluate the efficacy of treatment of drooling by ultrasound-guided botulinum toxin injection of the salivary glands and to determine the optimal modalities of this procedure.
This study is a retrospective review of patients treated for drooling by injection of 100 units of Botox(®) into the parotid and submaxillary glands between 2002 and 2008. Efficacy was evaluated by a quality of life questionnaire six weeks after the injections.
One hundred and eleven injection sessions were performed in 70 patients aged one to 84 years with a beneficial effect in 66% of cases. The most effective protocol was injection of 20 units of botulinum toxin into each submaxillary gland and 30 units of toxin into each parotid gland.
The treatment of drooling by Botox(®) injections into salivary glands is effective. The authors propose ultrasound-guided injection of both submaxillary glands and both parotid glands. These injections can be repeated in the case of recurrence of drooling.
评估超声引导下唾液腺肉毒毒素注射治疗流涎的疗效，并确定该方法的最佳方式。
这是一项回顾性研究，对 2002 年至 2008 年间，100 名患有流涎症的患者，采用 100 个单位的肉毒杆菌素（Botox(®)）注射入腮腺和颌下腺进行治疗。注射后 6 周，通过生活质量问卷评估疗效。
70 名 1 至 84 岁患者共进行了 111 次注射，66%的患者有效。最有效的方案是向每个颌下腺注射 20 个单位的肉毒毒素，向每个腮腺注射 30 个单位的毒素。
超声引导下唾液腺肉毒毒素注射治疗流涎有效。作者建议向双侧颌下腺和腮腺注射肉毒毒素。如果流涎再次发生，可以重复这些注射。
