Sillanpää Saara, Sipilä Markku, Numminen Jura, Rautiainen Markus
Department of Otorhinolaryngology, Head and Neck Surgery, Tampere University Hospital and School of Medicine, University of Tampere, Tampere, Finland.
ORL J Otorhinolaryngol Relat Spec. 2015;77(6):333-8. doi: 10.1159/000439175. Epub 2015 Sep 30.
Botulinum toxin A (BTX-A) injections to the salivary glands are effective in the treatment of drooling, and complications are rare. However, there are only a few previous reports on the long-term use of BTX-A injections. This study retrospectively analyzes our experience of treating drooling with repeated BTX-A injections in patients with neurodegenerative diseases. All patients who received repeated BTX-A injections to the submandibular glands at Tampere University Hospital in 2004-2013 were included in the analysis. Six patients, aged from 6 to 21 years, were included in the study, and a total of 41 bilateral BTX-A injections were administered to their submandibular glands. The average number of injections per patient was 6 (range: 3-11). The average interval between the injections was 9.8 months (range: 4-18), and 95% (39/41) of the injections were performed with good response. The complication rate of the BTX-A injections was 2.4% (1/41), since one of the patients had swallowing problems after an injection. BTX-A injections to the submandibular glands are effective and have a low morbidity rate, and repeated injections can be recommended as long-term treatment of drooling.
向唾液腺注射A型肉毒杆菌毒素（BTX-A）治疗流涎有效，且并发症罕见。然而，此前关于长期使用BTX-A注射治疗的报道较少。本研究回顾性分析了我们对神经退行性疾病患者反复注射BTX-A治疗流涎的经验。纳入分析的患者为2004年至2013年在坦佩雷大学医院接受反复下颌下腺BTX-A注射的所有患者。研究纳入了6名年龄在6至21岁之间的患者，共对其下颌下腺进行了41次双侧BTX-A注射。每位患者的平均注射次数为6次（范围：3至11次）。注射的平均间隔时间为9.8个月（范围：4至18个月），95%（39/41）的注射有良好反应。BTX-A注射的并发症发生率为2.4%（1/41），因为有一名患者在注射后出现吞咽问题。向下颌下腺注射BTX-A有效且发病率低，反复注射可作为流涎的长期治疗方法。
