Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK.
DNA Repair (Amst). 2011 Jul 15;10(7):730-3. doi: 10.1016/j.dnarep.2011.04.023. Epub 2011 May 20.
The late steps of nucleotide excision repair, following incisions to remove the damaged section of DNA, comprise repair synthesis and ligation. In vitro and in vivo studies have shown the size of the repaired patch to be about 30 nucleotides. In vitro studies implicated the replicative polymerases in repair synthesis, but recent in vivo data have shown that several DNA polymerases and ligases are involved in these steps in human cells.
核苷酸切除修复的后期步骤，在对 DNA 损伤部位进行切割后，包括修复合成和连接。体外和体内研究表明，修复后的补丁大小约为 30 个核苷酸。体外研究表明，复制聚合酶参与修复合成，但最近的体内数据表明，在人类细胞中，有几种 DNA 聚合酶和连接酶参与这些步骤。
