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细菌和人类中DNA切除修复的分子机制及基因组图谱。

Molecular mechanisms and genomic maps of DNA excision repair in and humans.

作者信息

Hu Jinchuan, Selby Christopher P, Adar Sheera, Adebali Ogun, Sancar Aziz

机构信息

From the Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7260 and.

the Department of Microbiology and Molecular Genetics, Hebrew University-Hadassah Medical School, Ein Kerem 71120, Jerusalem, Israel.

出版信息

J Biol Chem. 2017 Sep 22;292(38):15588-15597. doi: 10.1074/jbc.R117.807453. Epub 2017 Aug 10.

DOI:10.1074/jbc.R117.807453
PMID:28798238
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5612094/
Abstract

Nucleotide excision repair is a major DNA repair mechanism in all cellular organisms. In this repair system, the DNA damage is removed by concerted dual incisions bracketing the damage and at a precise distance from the damage. Here, we review the basic mechanisms of excision repair in and humans and the recent genome-wide mapping of DNA damage and repair in these organisms at single-nucleotide resolution.

摘要

核苷酸切除修复是所有细胞生物中的一种主要DNA修复机制。在这个修复系统中，DNA损伤通过在损伤两侧进行协调一致的双切口切除，且切口与损伤保持精确距离。在此，我们综述了细菌和人类中切除修复的基本机制，以及近期在这些生物中以单核苷酸分辨率对DNA损伤和修复进行的全基因组图谱绘制。

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