印度南部一家专科糖尿病中心 1992 年至 2009 年间收治的年轻糖尿病患者的临床特征。

Clinical profile of diabetes in the young seen between 1992 and 2009 at a specialist diabetes centre in south India.

机构信息

Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, WHO Colloborating Centre for Non-communicable Diseases Prevention and Control, IDF Centre for Education, 4, Conran Smith Road, Gopalapuram, Chennai 600086, India.

出版信息

Prim Care Diabetes. 2011 Dec;5(4):223-9. doi: 10.1016/j.pcd.2011.04.003. Epub 2011 May 23.

DOI:10.1016/j.pcd.2011.04.003

PMID:21601548

Abstract

AIM

To describe the trends and clinical profile of young diabetic patients (YD) attending a tertiary diabetes centre in south India.

METHODS

We reviewed medical records of 2630 YD patients (age at onset ≤25 years) registered between 1992 and 2009. Patients were classified as type 1 diabetes (T1DM), type 2 diabetes (T2DM) gestational diabetes mellitus (GDM) and other types. Retinopathy was assessed initially by direct and indirect ophthalmoscopy and later by retinal photography, nephropathy if urine protein excretion was >500 mg/day, neuropathy if vibration perception threshold on biothesiometry was ≥20 V.

RESULTS

The percentage of YD patients rose from 0.55% in 1992 to 2.5% in 2009 (trend chi square, 15.1, p<0.001). Of the 2630 YD subjects registered, 1135 (43.2%) had T1DM, 1262 (48.0%) had T2DM, 118 (4.5%) had GDM and 115 (4.4%) other types. T1DM patients were younger, had lower body mass index, waist circumference, systolic and diastolic blood pressures, and less family history of diabetes compared to T2DM (p<0.001 for each). Retinopathy was seen in 71.9% and 77.3% nephropathy in 22.1% and 12.1% and neuropathy in 34.5% and 21.4% of T2DM and T1DM respectively in those with ≥15 years duration of diabetes.

CONCLUSIONS

The percentage of YD in south India is increasing, predominantly due to early onset T2DM.

摘要

目的

描述在印度南部一家三级糖尿病中心就诊的年轻糖尿病患者（YD）的趋势和临床特征。

方法

我们回顾了 1992 年至 2009 年间登记的 2630 名 YD 患者（发病年龄≤25 岁）的病历。患者分为 1 型糖尿病（T1DM）、2 型糖尿病（T2DM）、妊娠期糖尿病（GDM）和其他类型。最初通过直接和间接眼底镜检查评估视网膜病变，然后通过视网膜摄影检查，尿蛋白排泄量>500mg/天则评估肾病，生物感觉阈值>20V 则评估神经病变。

结果

YD 患者的比例从 1992 年的 0.55%上升到 2009 年的 2.5%（趋势卡方检验，15.1，p<0.001）。在登记的 2630 名 YD 患者中，1135 名（43.2%）患有 T1DM，1262 名（48.0%）患有 T2DM，118 名（4.5%）患有 GDM，115 名（4.4%）患有其他类型。与 T2DM 相比，T1DM 患者年龄更小，体重指数、腰围、收缩压和舒张压更低，且糖尿病家族史更少（p<0.001）。在病程≥15 年的患者中，T2DM 和 T1DM 分别有 71.9%和 77.3%出现视网膜病变，22.1%和 12.1%出现肾病，34.5%和 21.4%出现神经病变。