印度南部1型糖尿病患者中代谢综合征的患病率及临床特征
Prevalence and clinical profile of metabolic syndrome among type 1 diabetes mellitus patients in southern India.
作者信息
Billow Amy, Anjana Ranjit Mohan, Ngai Michelle, Amutha Anandakumar, Pradeepa Rajendra, Jebarani Saravanan, Unnikrishnan Ranjit, Michael Edwin, Mohan Viswanathan
机构信息
Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, USA.
Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-communicable Diseases Prevention and Control, IDF Centre of Education, Gopalapuram, Chennai, India.
出版信息
J Diabetes Complications. 2015 Jul;29(5):659-64. doi: 10.1016/j.jdiacomp.2015.03.014. Epub 2015 Apr 6.
AIM
To assess the prevalence of metabolic syndrome (MetS) among patients with type 1 diabetes mellitus(T1DM) and to look at prevalence of diabetes complications in T1DM with and without MetS.
METHODS
We studied 451 T1DM patients attending a tertiary diabetes centre in Chennai, South India. T1DM was diagnosed based on absence of beta cell reserve and requirement of insulin from the time of diagnosis. Data on clinical and biochemical characteristics as well as complications details to study the prevalence were also extracted from electronic records. T1DM patients were divided into those with and without MetS[diagnosed according to the harmonizing the metabolic syndrome criteria(IDF/NHLBI/AHA/WHF/IAS/IASO)].
RESULTS
The overall prevalence of MetS among T1DM was 22.2%(100/451). Patients with MetS were older, had longer diabetes duration, acanthosis nigricans, and increased serum cholesterol. In the unadjusted logistic regression analysis, retinopathy, nephropathy and neuropathy were associated with MetS. However after adjustment for age, gender, diabetes duration, HbA1C and BMI significant association was seen only between MetS and retinopathy [odds ratio (OR) 2.82, 95% CI 1.18-6.74, p = 0.020] and nephropathy [OR 4.92, 95% CI 2.59-9.33, p < 0.001].
CONCLUSION
Prevalence of MetS is high among Asian Indian T1DM patients, and its presence is associated with increased risk of diabetic retinopathy and nephropathy.
目的
评估1型糖尿病（T1DM）患者中代谢综合征（MetS）的患病率，并观察合并和不合并MetS的T1DM患者糖尿病并发症的患病率。
方法
我们研究了在印度南部金奈一家三级糖尿病中心就诊的451例T1DM患者。T1DM根据诊断时β细胞储备缺失及胰岛素需求情况进行诊断。还从电子记录中提取了有关临床和生化特征以及用于研究患病率的并发症详细信息。T1DM患者被分为合并和不合并MetS的两组[根据统一代谢综合征标准（IDF/NHLBI/AHA/WHF/IAS/IASO）进行诊断]。
结果
T1DM患者中MetS的总体患病率为22.2%（100/451）。合并MetS的患者年龄较大，糖尿病病程较长，有黑棘皮病，血清胆固醇升高。在未调整的逻辑回归分析中，视网膜病变、肾病和神经病变与MetS相关。然而，在对年龄、性别、糖尿病病程、糖化血红蛋白（HbA1C）和体重指数（BMI）进行调整后，仅在MetS与视网膜病变[比值比（OR）2.82，95%置信区间（CI）1.18 - 6.74，p = 0.020]和肾病[OR 4.92，95% CI 2.59 - 9.33，p < 0.001]之间发现显著关联。
结论
亚洲印度T1DM患者中MetS的患病率较高，其存在与糖尿病视网膜病变和肾病风险增加相关。
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