Anjana Ranjit Mohan, Deepa Mohan, Pradeepa Rajendra, Amutha Anandakumar, Sridevi Kothandapani, Sathishraj Sekar, Menaka Sadasivam, Vijayabaskar Santhappan, Elangovan Nirmal, Parthiban Kumar, Dhanasekaran Lakshamanan, Hemavathy Saite, Tandon Nikhil, Kaur Tanvir, Dhaliwal Rupinder Singh, Unnikrishnan Ranjit, Mohan Viswanathan
Department of Diabetology, Madras Diabetes Research Foundation & Dr.Mohan's Diabetes Specialities Centre, Chennai, Tamil Nadu, India.
Department of Epidemiology, Madras Diabetes Research Foundation, Chennai, Tamil Nadu, India.
Indian J Med Res. 2024 Nov;160(5):514-526. doi: 10.25259/IJMR_1036_2024.
Background & objectives Biobanks are crucial for biomedical research, enabling new treatments and medical advancements. The biobank at the Madras Diabetes Research Foundation (MDRF) aims to gather, process, store, and distribute biospecimens to assist scientific studies. Methods This article details the profile of two cohorts: the Indian Council of Medical Research-India Diabetes (ICMR-INDIAB) study and the Registry of people with diabetes in India with young age at onset (ICMR-YDR). The ICMR-INDIAB study is the largest epidemiological study on diabetes in India, encompassing a nationally representative sample of individuals aged 20 yr and older from urban and rural areas in every State across the country. The ICMR-YDR is the first national-level, multicentric clinic-based registry focusing on youth-onset diabetes in India, aiming to understand the disease patterns and variations in youth-onset diabetes across different country regions. Results Key operations at the MDRF biobank include collecting and processing samples, where serum and whole blood samples are aliquoted and transferred through a cold chain to the central laboratory, and then stored in Siruseri (29 km from the capital city of Chennai, Tamil Nadu). Samples are barcoded, linked to subject information, and stored in freezers or liquid nitrogen (LN2) vessels, with inventory tracked via software for easy retrieval. A register records access to the biobank, ensuring sample integrity and compliance with regulatory requirements. The biobank adheres to the ICMR's National Ethical Guidelines for Biomedical and Health Research involving human participants. Interpretation & conclusions The biobank enables the analysis of biomarkers in stored samples, aiding in scientifically sound decisions, treating patients, and potentially curing diabetes.
背景与目标 生物样本库对生物医学研究至关重要，有助于实现新的治疗方法和医学进步。马德拉斯糖尿病研究基金会（MDRF）的生物样本库旨在收集、处理、储存和分发生物样本，以协助科学研究。方法 本文详细介绍了两个队列的概况：印度医学研究理事会-印度糖尿病（ICMR-INDIAB）研究和印度青年发病糖尿病患者登记册（ICMR-YDR）。ICMR-INDIAB研究是印度最大的糖尿病流行病学研究，涵盖了来自全国各州城乡地区、年龄在20岁及以上的具有全国代表性的个体样本。ICMR-YDR是印度首个国家级、多中心基于诊所的登记册，专注于青年发病糖尿病，旨在了解不同国家地区青年发病糖尿病的疾病模式和差异。结果 MDRF生物样本库的关键操作包括样本的收集和处理，血清和全血样本被分装并通过冷链转运至中央实验室，然后储存在西鲁塞里（距离泰米尔纳德邦首府金奈29公里）。样本被条形码编码，与受试者信息相关联，并储存在冰箱或液氮容器中，通过软件跟踪库存以便于检索。一本登记册记录对生物样本库的访问情况，确保样本完整性并符合监管要求。该生物样本库遵守ICMR关于涉及人类受试者的生物医学和健康研究的国家伦理准则。解读与结论 该生物样本库能够对储存样本中的生物标志物进行分析，有助于做出科学合理的决策、治疗患者并有可能治愈糖尿病。
