Fu Wen-jin, Zheng Lei, Wang Qian, Deng Ren-tang, Ye Chang-qin, Wang Shao-bo, Peng Lan-fen, Xiong Shi-long, Tang Hui-hua
Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2011 May;31(5):878-81.
To examine the urinary level of tissue factor (uTF) and its procoagulant activity (PCA) in patients with diabetes mellitus, and explore the relationship between uTF and renal damage in diabetes mellitus.
Eighty-six patients with type 2 diabetes mellitus were divided into 3 groups according to urine albumin excretion (UACR), namely normal albuminuria group, microalbuminuria group and macroalbuminuria group. The levels of uTF, PCA, blood urea nitrogen (BUN), serum creatinine (CRE), serum cystatin C (CYSC), glycohemoglobin A1c (HbA1c), and high-sensitivity C-reactive protein (hs-CRP) were measured in all the patients and 21 healthy controls.
Compared with normal control, the diabetic patients showed significantly increased levels of uTF and PCA. The urinary TF-PCA was positively correlated to BUN, CYSC, CRE, UACR, fasting glucose and hs-CRP, but not to uTF; only hs-CRP, UACR were positively correlated to uTF.
uTF is probably implicated in the development and progression of diabetic nephropathy.
检测糖尿病患者尿组织因子（uTF）水平及其促凝活性（PCA），探讨uTF与糖尿病肾损害的关系。
86例2型糖尿病患者根据尿白蛋白排泄率（UACR）分为3组，即正常蛋白尿组、微量白蛋白尿组和大量白蛋白尿组。检测所有患者及21名健康对照者的uTF、PCA、血尿素氮（BUN）、血清肌酐（CRE）、血清胱抑素C（CYSC）、糖化血红蛋白A1c（HbA1c）和高敏C反应蛋白（hs-CRP）水平。
与正常对照相比，糖尿病患者的uTF和PCA水平显著升高。尿TF-PCA与BUN、CYSC、CRE、UACR、空腹血糖和hs-CRP呈正相关，但与uTF无关；仅hs-CRP和UACR与uTF呈正相关。
uTF可能参与糖尿病肾病的发生发展。
