Li Yu-yang, Dai Yong-jiang, Deng Bin, Liang Xiong-an, Xie Zhi-jie, Chen Hai-fu
Department of Dermatology, Hainan Province Nongken Sanya Hospital, Sanya, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2011 May;31(5):917-8.
To detect the expression of stem cell transcription factor Oct-4 in squamous cell carcinoma (SCC) and seborrheic keratosis (SK) and its association with cancer stem cells.
Immunohistochemistry was used to detect Oct-4 expression in 35 SCC cases, 21 SK cases and 15 normal control skin tissues.
Oct-4 expression was negative in normal skin and showed a significant difference between SCC and SK tissues (P<0.05).
The Oct-4-positive cells in SCC and SK are probably tumor stem cells. Oct-4 expression may provide an important evidence for isolation and identification of human SCC and SK stem cells.
检测干细胞转录因子Oct-4在鳞状细胞癌（SCC）和脂溢性角化病（SK）中的表达及其与癌症干细胞的关系。
采用免疫组织化学法检测35例SCC病例、21例SK病例和15例正常对照皮肤组织中Oct-4的表达。
Oct-4在正常皮肤中表达为阴性，且在SCC和SK组织之间存在显著差异（P<0.05）。
SCC和SK中的Oct-4阳性细胞可能是肿瘤干细胞。Oct-4表达可能为人类SCC和SK干细胞的分离和鉴定提供重要证据。
