Department of Internal Medicine, National Taiwan University Hospital, Taipei,Taiwan.
Nephrol Dial Transplant. 2011 Dec;26(12):4068-73. doi: 10.1093/ndt/gfr209. Epub 2011 May 19.
Periodontitis and metabolic syndrome are highly prevalent in hemodialysis (HD) patients but little information is available on their association. Thus, this study aimed to assess the association between these two conditions in a HD cohort.
Data from 253 HD patients were analyzed. The association of periodontitis, gingival inflammation and dental plaque burden with metabolic syndrome and its individual component conditions were evaluated. Adjustments for age, gender, socioeconomic status, comorbidity and smoking status were considered.
The prevalence of metabolic syndrome was 65.1% among individuals (n = 149) with moderate-severe periodontitis, 54.5% among individuals (n = 55) with mild periodontitis and 36.7% among individuals (n = 49) without periodontitis. After adjustment of confounders, patients with moderate-severe periodontitis were 2.736 [95% confidence interval (CI), 1.293-5.790] times more likely to develop metabolic syndrome than were those without periodontitis. In addition, the odds ratio for metabolic syndrome was 1.561 (95% CI, 1.121-2.166) per score of gingival inflammation severity and 1.724 (95% CI, 1.135-12.615) per score of dental plaque burden.
Moderate-severe periodontitis is associated with metabolic syndrome in HD patients. Whether improved oral health reduces the risk of metabolic syndrome is worth determining through further studies.
牙周炎和代谢综合征在血液透析（HD）患者中高发，但关于两者之间关联的信息有限。因此，本研究旨在评估 HD 患者队列中这两种疾病之间的关联。
分析了 253 名 HD 患者的数据。评估了牙周炎、牙龈炎症和牙菌斑负担与代谢综合征及其各组成条件的关联。考虑了年龄、性别、社会经济地位、合并症和吸烟状况的调整。
中重度牙周炎患者（n = 149）中代谢综合征的患病率为 65.1%，轻度牙周炎患者（n = 55）中为 54.5%，无牙周炎患者（n = 49）中为 36.7%。调整混杂因素后，中重度牙周炎患者发生代谢综合征的可能性是无牙周炎患者的 2.736 倍（95%置信区间[CI]，1.293-5.790）。此外，牙龈炎症严重程度每增加 1 分，代谢综合征的比值比为 1.561（95%CI，1.121-2.166），牙菌斑负担每增加 1 分，比值比为 1.724（95%CI，1.135-12.615）。
中重度牙周炎与 HD 患者的代谢综合征相关。通过进一步的研究来确定改善口腔健康是否可以降低代谢综合征的风险是值得的。
