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牙周炎可能是韩国人代谢综合征的相关因素:一项病例对照研究。

Periodontitis could be related factors on metabolic syndrome among Koreans: a case-control study.

机构信息

Department of Preventive and Social Dentistry, School of Dentistry, Seoul National University, Seoul, Korea.

出版信息

J Clin Periodontol. 2012 Jan;39(1):30-7. doi: 10.1111/j.1600-051X.2011.01806.x. Epub 2011 Oct 31.

Abstract

AIM

Several studies have suggested that metabolic disorders are related to periodontitis. The objective of this study is to assess whether periodontitis is associated with the metabolic syndrome (MetS) among Koreans.

MATERIAL AND METHODS

This case-control study was performed among 167 cases with MetS and 166 healthy controls from Shiwha-Banwol Environmental Health Cohort (N = 1853). The community periodontal index (CPI) was used to assess periodontitis (CPI 3-4). MetS was an outcome variable and periodontitis was a main explanatory variable. Age-gender-matched conditional logistic regression models were applied. Monthly household income, smoking, drinking, physical activity and diabetes mellitus were factored as confounders. We also performed stratified analyses according to confounders.

RESULTS

Those with periodontitis are more likely to be patients with MetS than those without periodontitis. The adjusted odds ratio of periodontitis for MetS was 1.76. There was no significant dose-effect response on the relationship between the number of sextants with periodontitis and MetS. Links became higher in adults aged 45-60 years and adults without diabetes mellitus.

CONCLUSIONS

These results suggest that periodontitis could be an independently related factor on MetS. Hence, dentists and physicians should be aware of the importance of periodontitis as a potential source of inflammatory burden.

摘要

目的

多项研究表明代谢紊乱与牙周炎有关。本研究旨在评估韩国人群中牙周炎是否与代谢综合征(MetS)相关。

材料和方法

本病例对照研究在 Shiwha-Banwol 环境健康队列中进行,共纳入 167 例 MetS 患者和 166 例健康对照者(N=1853)。采用社区牙周指数(CPI)评估牙周炎(CPI 3-4)。MetS 为因变量,牙周炎为主要解释变量。采用年龄性别匹配的条件逻辑回归模型进行分析。将月家庭收入、吸烟、饮酒、体力活动和糖尿病等因素作为混杂因素进行校正。我们还根据混杂因素进行了分层分析。

结果

患有牙周炎的患者比没有牙周炎的患者更有可能患有 MetS。牙周炎发生 MetS 的调整比值比为 1.76。牙周炎六区数与 MetS 之间的关系无明显剂量-效应关系。在 45-60 岁的成年人和没有糖尿病的成年人中,这种关联更高。

结论

这些结果表明,牙周炎可能是 MetS 的一个独立相关因素。因此,牙医和内科医生应认识到牙周炎作为炎症负担潜在来源的重要性。

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