Gomes Samira V, Rodrigues Vandilson, Nunes-Dos-Santos Danila L, Pereira Antonio L A, Peres Marco A
Dentistry Graduate Program, Federal University of Maranhão, Avenida Dos Portugueses, São Luís, 196665080-805, Brazil.
School of Dentistry and Oral Health, Griffith University, Gold Coast, QLD, Australia.
Clin Oral Investig. 2022 Jan;26(1):397-406. doi: 10.1007/s00784-021-04011-6. Epub 2021 Jul 1.
Several factors have been associated with hyperglycemia after kidney transplantation (KTx), including systemic inflammation. This study aimed to investigate the relationship between periodontal status and hyperglycemia in KTx patients.
Forty-four KTx patients were included in this cross-sectional study. Periodontitis severity was categorized into stage I to IV. Fasting blood glucose (FBG) was measured, and hyperglycemia was analyzed at different FBG cutoff points (100 mg/dL, 110 mg/dL, 120 mg/dL, 126 mg/dL, 140 mg/dL). Age, history of smoking, prior type 2 diabetes (T2D), and prior cardiovascular disease (CVD) were considered cofounders. Multivariable logistic regression modelling was performed with periodontitis as the exposure and hyperglycemia as the outcome. Pathway analysis was performed with FBG as a continuous outcome.
Periodontitis had increased odds of hyperglycemia from 120 mg/dL FBG cutoff, even after adjustment. In addition, periodontitis severity was positively associated with FBG level (β = 0.323, SE = 0.127, P = 0.011).
The findings suggest that periodontitis may be related to increase of hyperglycemia and FBG levels in KTx patients.
Periodontitis severity and cardiovascular disease were positively associated with FBG levels in KTx patients. Clinicians and patients should be aware of the potential benefit of periodontal care for better glycemic control management.
肾移植（KTx）术后高血糖与多种因素有关，包括全身炎症。本研究旨在探讨KTx患者牙周状况与高血糖之间的关系。
本横断面研究纳入了44例KTx患者。牙周炎严重程度分为I至IV期。测量空腹血糖（FBG），并在不同的FBG切点（100mg/dL、110mg/dL、120mg/dL、126mg/dL、140mg/dL）分析高血糖情况。年龄、吸烟史、既往2型糖尿病（T2D）和既往心血管疾病（CVD）被视为混杂因素。以牙周炎为暴露因素、高血糖为结局进行多变量逻辑回归建模。以FBG作为连续结局进行通路分析。
即使经过校正，牙周炎在FBG切点为120mg/dL时高血糖几率仍增加。此外，牙周炎严重程度与FBG水平呈正相关（β = 0.323，SE = 0.127，P = 0.011）。
研究结果表明，牙周炎可能与KTx患者高血糖及FBG水平升高有关。
KTx患者牙周炎严重程度和心血管疾病与FBG水平呈正相关。临床医生和患者应意识到牙周护理对更好地控制血糖管理的潜在益处。
