Unité des Aspergillus, Institut Pasteur, 25 Rue du Docteur Roux, 75015 Paris, France.
Appl Environ Microbiol. 2011 Jul;77(13):4700-3. doi: 10.1128/AEM.00243-11. Epub 2011 May 20.
MgtC is important for the survival of several bacterial pathogens in macrophages and for growth under magnesium limitation. Among eukaryotes, a gene homologous to mgtC was found only in the pathogenic fungus Aspergillus fumigatus. Our data show that the A. fumigatus MgtC (AfuMgtC) protein does not have the same function as the bacterial MgtC proteins.
MgtC 对于几种在巨噬细胞中存活的细菌病原体以及在镁限制下的生长非常重要。在真核生物中,只有致病性真菌烟曲霉中发现了与 mgtC 同源的基因。我们的数据表明,烟曲霉 MgtC(AfuMgtC)蛋白的功能与细菌 MgtC 蛋白不同。