Jaspers R M, de Vries T J, Cools A R
Psychoneuropharmacological Research Unit, University of Nijmegen, The Netherlands.
Behav Brain Res. 1990 Mar 26;37(3):237-46. doi: 10.1016/0166-4328(90)90135-2.
The effect of caudate nucleus (CN)-injections of the glutamate agonist DL-alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA), viz. an agonist of quisqualate receptors, on switching behaviour was investigated: first, cats had to switch from hanging with the forepaws on the bar to climbing on the bar; then, they had to switch to walking; finally, they had to switch to jumping off the bar. AMPA induced limb deficits, i.e. unilateral incorrect or absent placing of the fore- and/or hindlimb, in part of the tested cats; in the remainder of the tested animals AMPA reduced climbing time. Limb deficits were prevented by the broad-spectrum glutamate antagonist kynurenic acid (KYN) and by the selective NMDA antagonist D-2-amino-7-phosphono-heptanoate. In all cats AMPA increased the number of head movements as well as that of walking-restarts. These effects were counteracted only by KYN. These data show that part of the AMPA-induced effects were selectively mediated by quisqualate receptors. The present data are discussed in view of the role of the caudate nucleus in switching behaviour.
研究了向尾状核（CN）注射谷氨酸激动剂DL-α-氨基-3-羟基-5-甲基异恶唑-4-丙酸（AMPA）（即quisqualate受体的激动剂）对转换行为的影响：首先，猫必须从前爪挂在横杆上转换为攀爬横杆；然后，它们必须转换为行走；最后，它们必须转换为从横杆上跳下。AMPA在部分受试猫中诱发了肢体缺陷，即前肢和/或后肢单侧放置不正确或缺失；在其余受试动物中，AMPA缩短了攀爬时间。广谱谷氨酸拮抗剂犬尿氨酸（KYN）和选择性NMDA拮抗剂D-2-氨基-7-磷酸庚酸可预防肢体缺陷。在所有猫中，AMPA增加了头部运动的次数以及行走重新开始的次数。这些效应仅被KYN抵消。这些数据表明，AMPA诱导的部分效应是由quisqualate受体选择性介导的。鉴于尾状核在转换行为中的作用，对目前的数据进行了讨论。
