Division of Pediatric Endocrinology, Diabetes and Metabolism, University of South Florida and All Children's Hospital, St Petersburg, Florida, USA.
Curr Opin Pediatr. 2011 Aug;23(4):452-9. doi: 10.1097/MOP.0b013e32834810e5.
This article reviews the genetics, biochemistry, and physiology of the natriuretic polypeptide family and their receptors; their roles in cardiac, bone, and lipid metabolism in children; and pharmacological agents that utilize the natriuretic polypeptide system.
Clinically, measurements of circulating levels of the natriuretic polypeptides are useful diagnostic and prognostic markers of cardiovascular disease in children. The natriuretic polypeptides also play an important role in growth and body composition. Therapeutic application of the natriuretic polypeptide system may provide new treatments for cardiac, renal, bone, and metabolic disease in children.
The natriuretic polypeptide system has promising clinical utility in the care of pediatric patients with cardiac, renal, bone, and metabolic disease.
本文综述了利钠肽家族及其受体的遗传学、生物化学和生理学；它们在儿童心脏、骨骼和脂质代谢中的作用；以及利用利钠肽系统的药理学制剂。
临床上，循环利钠肽水平的测量是儿童心血管疾病有用的诊断和预后标志物。利钠肽在生长和身体成分中也起着重要作用。利钠肽系统的治疗应用可能为儿科心脏、肾脏、骨骼和代谢疾病提供新的治疗方法。
利钠肽系统在儿科心脏、肾脏、骨骼和代谢疾病患者的治疗中有很好的临床应用前景。
