Szabó Gábor, Rigó János, Nagy Bálint
Semmelweis Egyetem, Általános Orvostudományi Kar, I., Szülészeti és Nőgyógyászati Klinika, Budapest.
Orv Hetil. 2011 Jun 26;152(26):1025-34. doi: 10.1556/OH.2011.29153.
In the last three decades many members of the natriuretic peptide family was isolated. The function and physiological role of these peptides are pleiotropic. All natriuretic peptides are synthesized from polypeptide precursors. Together with the sympathetic nervous system and other hormones they play key roles, like an endogenous system in the regulation of the body fluid homeostasis and blood pressure. Changes in this balance lead to dysfunction in the endothel and left ventricle, which can cause severe complications. In many cardiovascular diseases natriuretic peptides serve not only as marker for diagnosis and prognosis but they have therapeutic importance. In the last years the potential use of the elevated BNP levels for diagnosis of pre-eclampsia was examined. In our review we discuss the current understanding of molecular biology, biochemistry and clinical relevance of natriuretic peptides.
在过去三十年中，许多利钠肽家族成员被分离出来。这些肽的功能和生理作用具有多效性。所有利钠肽均由多肽前体合成。它们与交感神经系统及其他激素一起发挥关键作用，就像调节体液平衡和血压的内源性系统一样。这种平衡的改变会导致内皮和左心室功能障碍，进而引发严重并发症。在许多心血管疾病中，利钠肽不仅作为诊断和预后的标志物，还具有治疗意义。近年来，人们研究了升高的脑钠肽（BNP）水平在子痫前期诊断中的潜在用途。在我们的综述中，我们讨论了目前对利钠肽分子生物学、生物化学及临床相关性的理解。
