Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland.
J Neurogastroenterol Motil. 2011 Apr;17(2):140-7. doi: 10.5056/jnm.2011.17.2.140. Epub 2011 Apr 27.
That gastrointestinal motility can influence the gut microbiota has been known for decades and the clinical consequences of impaired motility, in terms of the bacterial population of the small intestine, amply illustrated by the syndrome of small intestinal bacterial overgrowth which so commonly accompanies diffuse intestinal motility disorders. As the importance of the microbiota to homeostasis in health and to a variety of disease states is increasingly appreciated and as the full diversity and biology of this "hidden organ" have been revealed by molecular methodologies, the true nature of the interaction between the microbiota and motility is being re-examined and the complexity of this relationship exposed. In health, as well as in disease states, this is a truly bi-directional relationship: not only can gut motor patterns influence the microbiota but changes in the microbiota can exert profound influences on gut sensori-motor function.
几十年来，人们一直都知道胃肠道动力会影响肠道微生物群，而且，肠道动力受损会导致小肠细菌过度生长综合征等临床后果，这种综合征通常伴随着弥漫性肠道运动障碍，充分说明了这一点。随着人们越来越认识到微生物群对健康和各种疾病状态下的体内平衡的重要性，以及分子方法学揭示了这个“隐藏器官”的全部多样性和生物学特性，微生物群与动力之间的相互作用的真正性质正在被重新审视，这种关系的复杂性也正在被揭示。无论是在健康状态还是疾病状态下，这都是一种真正的双向关系：不仅肠道运动模式会影响微生物群，而且微生物群的变化也会对肠道感觉运动功能产生深远影响。
