Haley Gwendolen E, Urbanski Henryk F, Kohama Steven G, Messaoudi Ilhem, Raber Jacob
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239.
Eur Geriatr Med. 2011 Apr 1;2(2):117-121. doi: 10.1016/j.eurger.2011.01.002.
We recently reported that in aged female rhesus macaques, spatial learning and memory correlates with circadian sleep-wake measures and hippocampal muscarinic type 1 (M(1)) receptor binding. To investigate if spatial memory also correlates with measures of immune function, we now assessed the magnitude of the adaptive immune response to vaccination in the same old female rhesus macaques. Cognitively characterized animals were classified as good spatial performers (GSP) or poor spatial performers (PSP) based on performance in the Spatial Foodport maze. The GSP group had higher frequency of CD8, but not CD4, interferon-γ (IFN-γ) producing cells following vaccination compared to the PSP group, suggesting a stronger CD8 T cell response in the GSP group. In addition, the number of CD-8 IFN-γ positive cells correlated with measures of sleep quality. Interestingly, the PSP group had a significantly higher antibody titer compared to the GSP group, and antibody titer negatively correlated with day-time activity. Thus, in aged female rhesus macaques, superior cognitive performance is correlated with a more robust CD8 T cell response but a reduced antibody response to vaccination.
我们最近报告称，在老年雌性恒河猴中，空间学习和记忆与昼夜睡眠-觉醒指标以及海马毒蕈碱1型（M(1)）受体结合相关。为了研究空间记忆是否也与免疫功能指标相关，我们现在评估了相同老年雌性恒河猴对疫苗接种的适应性免疫反应强度。根据在空间食物端口迷宫中的表现，对认知特征明确的动物分为空间表现良好组（GSP）或空间表现较差组（PSP）。与PSP组相比，GSP组在接种疫苗后产生干扰素-γ（IFN-γ）的CD8细胞频率更高，但CD4细胞频率无差异，这表明GSP组的CD8 T细胞反应更强。此外，CD-8 IFN-γ阳性细胞数量与睡眠质量指标相关。有趣的是，PSP组的抗体滴度明显高于GSP组，且抗体滴度与白天活动呈负相关。因此，在老年雌性恒河猴中，卓越的认知表现与更强大的CD8 T细胞反应相关，但对疫苗接种的抗体反应降低。
