Abbott Marcia J, Tang Tianyi, Sul Hei Sook
Department of Nutritional Science and Toxicology, University of California, Berkeley, CA 94720 USA.
Drug Discov Today Dis Mech. 2010 Winter;7(3-4):e213-e218. doi: 10.1016/j.ddmec.2011.01.003.
Obesity has become an epidemic and its prevalence is increasing exponentially. A great deal of focus has been given to understanding the molecular processes that regulate obesity. The characterization of phospholipase A(2)s, especially adipose-specific PLA(2), have lead to a proposed role of their downstream products in the progression of obesity and obesity related disorders. This review summarizes recent developments in the role of PLA(2) and their downstream effects in the development of metabolic disorders.
肥胖已成为一种流行病，其患病率正呈指数级增长。人们已将大量精力集中于理解调节肥胖的分子过程。对磷脂酶A(2)，尤其是脂肪特异性磷脂酶A(2)的特性研究，已使人们提出其下游产物在肥胖及肥胖相关疾病进展中的作用。本综述总结了磷脂酶A(2)的作用及其下游效应在代谢紊乱发展方面的最新进展。
