Armutcu Ferah, Ozen Oguz Aslan
Department of Biochemistry, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
Department of Oncology and Metabolism, Medical School, University of Sheffield, Sanctuary International Visitor Support Scheme, Sheffield, United Kingdom.
Curr Aging Sci. 2023;16(2):97-111. doi: 10.2174/1874609816666230223110458.
Aging is characterized by progressive regression in tissue and organ functions and an increased risk of disease and death. Aging is also accompanied by chronic low-grade inflammation. Both obesity and aging are associated with the development of metabolic diseases, leading to an increase in the senescent cell burden in multiple organs. Chronic low-grade inflammation of adipose tissue is one of the mechanisms implicated in the progression of these diseases. As a real endocrine organ, adipose tissue secretes many mediators and hormones (adipokines) to maintain metabolic homeostasis, and their dysfunction has been causally linked to a wide range of metabolic diseases. Dysfunctional adipose tissue participates in interorgan communication both by producing new signaling mediators and by transforming or disrupting signal mediators, reaching from other organs. In addition to obesity and similar metabolic diseases, this situation causes dysfunction in more organs in the aging process, and the complexity of the problem causes challenges in the diagnosis and treatment processes. This review aims to highlight recent developments and current information supporting the relationship between obesity and adipose tissue dysfunction with aging and the role of homeostatic and physio-pathological processes that mediate interorgan communication in aging progress. More understanding clearly of interorgan communication in the process of obesity and aging will facilitate the early diagnosis as well as the management of treatment practices in short- and long-term organ dysfunction.
衰老的特征是组织和器官功能逐渐衰退，以及疾病和死亡风险增加。衰老还伴随着慢性低度炎症。肥胖和衰老都与代谢性疾病的发生有关，导致多个器官中衰老细胞负担增加。脂肪组织的慢性低度炎症是这些疾病进展所涉及的机制之一。作为一个真正的内分泌器官，脂肪组织分泌许多介质和激素（脂肪因子）以维持代谢稳态，其功能障碍与多种代谢性疾病存在因果关系。功能失调的脂肪组织通过产生新的信号介质以及通过转化或破坏来自其他器官的信号介质来参与器官间通讯。除了肥胖和类似的代谢性疾病外，这种情况还会在衰老过程中导致更多器官功能障碍，问题的复杂性给诊断和治疗过程带来挑战。本综述旨在强调支持肥胖和脂肪组织功能障碍与衰老之间关系的最新进展和当前信息，以及在衰老过程中介导器官间通讯的稳态和生理病理过程的作用。更清楚地了解肥胖和衰老过程中的器官间通讯将有助于早期诊断以及短期和长期器官功能障碍治疗实践的管理。
