Tennuci Christopher, Pearce Gillian, Wong Julian, Nayak Sanjeev, Jones Tom, Lally Frank, Roffe Christine
School of Medicine, Keele University, Staffordshire ST5 5BG, UK.
Stroke Res Treat. 2011;2011:186424. doi: 10.4061/2011/186424. Epub 2011 Apr 14.
Introduction. This paper compares different approaches to recanalization in a model of the middle cerebral artery (MCA). Methods. An occlusive thrombus (lamb's blood) was introduced into the MCA of a model of the cerebral circulation perfused with Hartmann's solution (80 pulsations/min, mean pressure 90 mm Hg). Three methods of clot retrieval were tested: thrombus aspiration via a 4F catheter (n = 26), thrombus aspiration via the GP thrombus aspiration device (GPTAD) (n = 30), and mechanical thrombectomy via the Solitaire Device (n = 30). Results. Recanalization rate was similar for all 3 approaches (62%, 77%, and 85%). Time to recanalization was faster with aspiration devices (41 SD 42 s for 4F and 61 SD 21 s for GPTAD) than with the Solitaire (197 SD 64 s P < .05 Kruksal-Wallis). Clot fragmentation was the same in the Solitaire (23%) and the GPTAD (23%), but higher with the 4F (53%, P < .05). Conclusion. In this model, thrombus aspiration was faster than mechanical thrombectomy, and similarly effective at recanalization. These results should be confirmed in vivo.
引言。本文比较了大脑中动脉（MCA）模型中不同的再通方法。方法。将闭塞性血栓（羊血）引入用哈特曼溶液灌注的脑循环模型的MCA中（80次搏动/分钟，平均压力90毫米汞柱）。测试了三种取栓方法：通过4F导管进行血栓抽吸（n = 26）、通过GP血栓抽吸装置（GPTAD）进行血栓抽吸（n = 30）以及通过Solitaire装置进行机械取栓（n = 30）。结果。所有三种方法的再通率相似（分别为62%、77%和85%）。与Solitaire装置相比，抽吸装置的再通时间更快（4F导管为41±42秒，GPTAD为61±21秒）（Kruksal-Wallis检验，P <.05）。Solitaire装置（23%）和GPTAD（23%）的血栓破碎情况相同，但4F导管的血栓破碎率更高（53%，P <.05）。结论。在该模型中，血栓抽吸比机械取栓更快，且再通效果相似。这些结果应在体内得到证实。
