组织蛋白酶D前体与癌症：从分子生物学到临床应用
Procathepsin D and cancer: From molecular biology to clinical applications.
作者信息
Vetvicka Vaclav, Vashishta Aruna, Saraswat-Ohri Sujata, Vetvickova Jana
机构信息
Vaclav Vetvicka, Jana Vetvickova, Department of Pathology, University of Louisville, Louisville, KY 40202, United States.
出版信息
World J Clin Oncol. 2010 Nov 10;1(1):35-40. doi: 10.5306/wjco.v1.i1.35.
Abstract
Procathepsin D (pCD) is overexpressed and secreted by cells of various tumor types including breast and lung carcinomas. pCD affects multiple features of tumor cells including proliferation, invasion, metastases and apoptosis. Several laboratories have previously shown that the mitogenic effect of pCD on cancer cells is mediated via its propeptide part (APpCD). However, the exact mechanism of how pCD affects cancer cells has not been identified. Recent observations have also revealed the possible use of pCD/APpcD as a marker of cancer progression. The purpose of this review is to summarize the three major potentials of pCD-tumor marker, potential drug, and screening agent.
摘要
前组织蛋白酶D（pCD）在包括乳腺癌和肺癌在内的多种肿瘤类型的细胞中过度表达并分泌。pCD影响肿瘤细胞的多个特征，包括增殖、侵袭、转移和凋亡。几个实验室先前已经表明，pCD对癌细胞的促有丝分裂作用是通过其前肽部分（APpCD）介导的。然而，pCD影响癌细胞的确切机制尚未明确。最近的观察还揭示了pCD/APpcD作为癌症进展标志物的可能用途。本综述的目的是总结pCD的三大潜在作用——肿瘤标志物、潜在药物和筛选剂。
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