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Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects.一种用于血管紧张素I的放射免疫测定法在正常人体血浆肾素活性生理测量中的应用。
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7
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8
Atrial natriuretic peptide release during sleep in patients with obstructive sleep apnoea before and during treatment with nasal continuous positive airway pressure.阻塞性睡眠呼吸暂停患者在接受鼻持续气道正压通气治疗前及治疗期间睡眠时心房利钠肽的释放情况。
Clin Sci (Lond). 1989 Oct;77(4):407-11. doi: 10.1042/cs0770407.
9
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10
Effects of treatment with nasal continuous positive airway pressure on atrial natriuretic peptide and arginine vasopressin release during sleep in patients with obstructive sleep apnoea.鼻腔持续气道正压通气治疗对阻塞性睡眠呼吸暂停患者睡眠期间心房利钠肽和精氨酸加压素释放的影响。
Clin Sci (Lond). 1991 May;80(5):443-9. doi: 10.1042/cs0800443.

睡眠呼吸暂停/低通气综合征患者的心房利钠肽水平

Atrial natriuretic peptide levels in the sleep apnoea/hypopnoea syndrome.

作者信息

Mackay T W, Fitzpatrick M F, Freestone S, Lee M R, Douglas N J

机构信息

Respiratory Medicine Unit, University of Edinburgh, UK.

出版信息

Thorax. 1994 Sep;49(9):920-1. doi: 10.1136/thx.49.9.920.

DOI:10.1136/thx.49.9.920
PMID:7940435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC475196/
Abstract

BACKGROUND

Patients with the sleep apnoea/hypopnoea syndrome have increased salt and water excretion at night which has been reported to be associated with an increase in plasma levels of atrial natriuretic peptide (ANP). A study was performed to determine whether any rise in plasma ANP levels was related to nocturnal hypoxaemia.

METHODS

Nine patients with sleep apnoea/hypopnoea syndrome were studied on two nights, one breathing air and the other 28% oxygen, the order being randomised. Venous levels of ANP, aldosterone, and renin activity were measured.

RESULTS

No decrease in plasma ANP levels on oxygen was seen, and, indeed, there was no evidence of an overnight increase in ANP levels.

CONCLUSION

Oxygen therapy does not diminish nocturnal plasma ANP levels in patients with sleep apnoea/hypopnoea syndrome.

摘要

背景

睡眠呼吸暂停/低通气综合征患者夜间盐和水排泄增加，据报道这与心房利钠肽（ANP）血浆水平升高有关。进行了一项研究以确定血浆ANP水平的任何升高是否与夜间低氧血症有关。

方法

对9名睡眠呼吸暂停/低通气综合征患者进行了两晚的研究，一晚呼吸空气，另一晚呼吸28%的氧气，顺序随机。测量了ANP、醛固酮和肾素活性的静脉水平。

结果

未观察到吸氧时血浆ANP水平降低，实际上，也没有证据表明ANP水平在夜间升高。

结论

氧疗不会降低睡眠呼吸暂停/低通气综合征患者的夜间血浆ANP水平。