睡眠呼吸暂停/低通气综合征患者的心房利钠肽水平
Atrial natriuretic peptide levels in the sleep apnoea/hypopnoea syndrome.
作者信息
Mackay T W, Fitzpatrick M F, Freestone S, Lee M R, Douglas N J
机构信息
Respiratory Medicine Unit, University of Edinburgh, UK.
出版信息
Thorax. 1994 Sep;49(9):920-1. doi: 10.1136/thx.49.9.920.
Abstract
BACKGROUND
Patients with the sleep apnoea/hypopnoea syndrome have increased salt and water excretion at night which has been reported to be associated with an increase in plasma levels of atrial natriuretic peptide (ANP). A study was performed to determine whether any rise in plasma ANP levels was related to nocturnal hypoxaemia.
METHODS
Nine patients with sleep apnoea/hypopnoea syndrome were studied on two nights, one breathing air and the other 28% oxygen, the order being randomised. Venous levels of ANP, aldosterone, and renin activity were measured.
RESULTS
No decrease in plasma ANP levels on oxygen was seen, and, indeed, there was no evidence of an overnight increase in ANP levels.
CONCLUSION
Oxygen therapy does not diminish nocturnal plasma ANP levels in patients with sleep apnoea/hypopnoea syndrome.
摘要
背景
睡眠呼吸暂停/低通气综合征患者夜间盐和水排泄增加，据报道这与心房利钠肽（ANP）血浆水平升高有关。进行了一项研究以确定血浆ANP水平的任何升高是否与夜间低氧血症有关。
方法
对9名睡眠呼吸暂停/低通气综合征患者进行了两晚的研究，一晚呼吸空气，另一晚呼吸28%的氧气，顺序随机。测量了ANP、醛固酮和肾素活性的静脉水平。
结果
未观察到吸氧时血浆ANP水平降低，实际上，也没有证据表明ANP水平在夜间升高。
结论
氧疗不会降低睡眠呼吸暂停/低通气综合征患者的夜间血浆ANP水平。
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