Ehrmann J
Ustav patologie a Laborator molekulární patologie LF UP a FN Olomouc.
Cesk Patol. 2011 Apr;47(2):50-1.
This review summarizes the highlights in hepatopathology presented during the Prague Hepatology Meeting 2010. Gut flora (microbiome) and intestinal permeability seems to play an important role during progression into liver cirrhosis in patients with non-alcoholic steatohepatitis. Molecular diagnosis allows the distinction of several types of hepatocellular adenoma with different risks of malignant progression. Experimental hepatology is currently focused on the role of epigenetics during pathogenesis of alcoholic liver disease. The most studied topic in viral hepatitis C is the mechanisms of resistance to antiviral treatment. Pathogenesis of liver fibrosis and the role of keratins in the pathology of liver disease are areas of scientific interest as well.
本综述总结了2010年布拉格肝病会议上肝病病理学的要点。肠道菌群(微生物组)和肠道通透性在非酒精性脂肪性肝炎患者进展为肝硬化的过程中似乎起着重要作用。分子诊断有助于区分几种具有不同恶性进展风险的肝细胞腺瘤。实验性肝病学目前聚焦于表观遗传学在酒精性肝病发病机制中的作用。丙型病毒性肝炎研究最多的话题是抗病毒治疗的耐药机制。肝纤维化的发病机制以及角蛋白在肝病病理学中的作用也是科学研究的热点领域。