Peking University 302 Clinical Medical School, Beijing, China.
Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China.
Cell Mol Immunol. 2021 Jan;18(1):38-44. doi: 10.1038/s41423-020-00560-0. Epub 2020 Nov 6.
Previously, it was assumed that peripheral neutrophils are a homogeneous population that displays antimicrobial functions. However, recent data have revealed that neutrophils are heterogeneous and are additionally involved in tissue damage and immune regulation. The phenotypic and functional plasticity of neutrophils has been identified in patients with cancer, inflammatory disorders, infections, and other diseases. Currently, neutrophils, with their autocrine, paracrine, and immune modulation functions, have been shown to be involved in liver diseases, including viral hepatitis, nonalcoholic steatohepatitis, alcoholic liver disease, liver fibrosis, cirrhosis, liver failure, and liver cancer. Accordingly, this review summarizes the role of neutrophils in liver diseases.
先前，人们认为外周血中性粒细胞是一种具有抗微生物功能的同质群体。然而，最近的数据表明，中性粒细胞具有异质性，并且还参与组织损伤和免疫调节。在癌症、炎症性疾病、感染和其他疾病患者中已经发现了中性粒细胞的表型和功能可塑性。目前，具有自分泌、旁分泌和免疫调节功能的中性粒细胞已被证明参与肝脏疾病，包括病毒性肝炎、非酒精性脂肪性肝炎、酒精性肝病、肝纤维化、肝硬化、肝衰竭和肝癌。因此，本综述总结了中性粒细胞在肝脏疾病中的作用。
