白细胞介素-1β基因-31T/C多态性与慢性鼻-鼻窦炎的关联
[Association of IL-1beta gene -31T/C polymorphism with chronic rhinosinusitis].
作者信息
Chen Nijun, Ni Peihua, Cai Changping, Wang Shili
机构信息
Department of Otolaryngology, Ruijin Hospital, Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
出版信息
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Mar;25(5):197-200.
OBJECTIVE
To investigate the relationship between polymorphism of IL-1beta gene 31T/C and chronic rhinosinusitis.
METHOD
One hundred and twenty-three patients with chronic rhinosinusitis and 239 healthy controls were collected to determine the genotypes by polymerase chain reaction-restriction fragment length polymorphism.
RESULT
There was significant difference in genotype and allelic frequencies between the CRS and control group (P < 0.05). -31CC genotype was an independent risk factor with CRS (P < 0.05, OR = 1.639). There was no significant difference in TIgE and ECP among these genotypes (P > 0.05).
CONCLUSION
IL-1beta gene 31CC genotype may be an independent risk factor with chronic rhinosinusitis.
目的
探讨白细胞介素-1β基因31T/C多态性与慢性鼻-鼻窦炎的关系。
方法
收集123例慢性鼻-鼻窦炎患者和239例健康对照者，采用聚合酶链反应-限制性片段长度多态性方法确定基因型。
结果
慢性鼻-鼻窦炎组与对照组的基因型和等位基因频率存在显著差异（P<0.05）。-31CC基因型是慢性鼻-鼻窦炎的独立危险因素（P<0.05，OR=1.639）。这些基因型之间的总IgE和嗜酸性粒细胞阳离子蛋白无显著差异（P>0.05）。
结论
白细胞介素-1β基因31CC基因型可能是慢性鼻-鼻窦炎的独立危险因素。
Zotero 插件