Ru Wei-Ping, Kang Kai, You Ai-Guo, Xia Sheng-Li
Center for Disease Control and Provention of Henan Province, Zhengzhou 450016, China.
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2010 Dec;24(6):448-50.
To explore the clinical and epidemiological characteristics of serious cases of hand-foot-and-mouth disease (HFMD) infected by EV71, in order to provide scientific evidence for prevention and control of HFMD.
Information was collected by questionaires through consulting medical cases. Data was input by Epidata, and analysed by software SAS 9.13.
201 severe cases were investigated. 84.65% of the cases were below 3 years old. The youngest one was 5 months and the oldest one was 8 years old. The ratio for male and female was 2.2: 1.85. 08% of the cases were distributed sporadically. 51.74% of them lived in rural, 29.36% of them lived in urban and 19.9% of them lived at the fringe area of rural and urban. 81.59% of the cases became serious between 1 and 4 days after infected. 100% cases had fever and 99.95% of them had a rash. 96.52% of them had nerve system symptoms. The main complications were virulent spinal encephalitis, pneumonia and breathing exhaustion. 98.01% of the patients were recovered or cured.
The cases aged below 3 years old are high risk persons. Rural area and the fringe area of rural and urban are the key area for disease control. 1-4 days after onset is the key period to prevent complications.
探讨肠道病毒71型（EV71）感染所致手足口病重症病例的临床和流行病学特征，为手足口病的防控提供科学依据。
通过查阅病历以问卷形式收集资料，数据录入Epidata，并用SAS 9.13软件进行分析。
共调查201例重症病例。84.65%的病例年龄在3岁以下，最小5个月，最大8岁，男女比例为2.2∶1.85。08%的病例呈散发性分布。51.74%的病例居住在农村，29.36%居住在城市，19.9%居住在城乡结合部。81.59%的病例在感染后1至4天病情加重。100%的病例有发热，99.95%的病例有皮疹，96.52%的病例有神经系统症状。主要并发症为病毒性脑脊髓炎、肺炎和呼吸衰竭。98.01%的患者康复或治愈。
3岁以下儿童为高危人群。农村及城乡结合部是疾病防控的重点区域。发病后1至4天是预防并发症的关键时期。
