Lewis S J, Shulkes A, Bodsworth B, Jarrott B
Clinical Pharmacology and Therapeutics Unit, University of Melbourne, Australia.
J Hypertens. 1990 Apr;8(4):315-9. doi: 10.1097/00004872-199004000-00004.
The regional brain and spinal cord concentrations of calcitonin gene-related peptide (CGRP) were measured in age-matched (22-23-week-old) spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. The highest concentration of CGRP in the WKY rats was in the spinal cord (172 +/- 9 pmol/g), followed by the medulla oblongata/pons (88 +/- 5 pmol/g). The relative order of distribution in the remaining regions was: hypothalamus (12.6 +/- 0.8 pmol/g) = striatum greater than thalamus greater than midbrain = hippocampus greater than cortex (2.1 +/- 0.3 pmol/g). The concentration of CGRP in the cerebellum was at the level of the assay's sensitivity (0.5 pmol/g). The relative order of distribution in the SHR strain was essentially the same. However, in comparison with the WKY rats, the SHR had significantly lower levels of CGRP in the hippocampus (-47%), striatum (-49%) and medulla oblongata/pons (-24%), and in the spinal cord (-24%). In younger age-matched (16-17-week-old) rats, the spinal cord and medulla oblongata/pons concentrations of CGRP were also lower in SHR than in WKY rats. CGRP is a putative neurotransmitter which, when administered centrally or peripherally, has potent cardiovascular effects. The reduced levels of this peptide may be an important factor in the cardiovascular and/or behavioural abnormalities of the SHR strain.
在年龄匹配（22 - 23周龄）的自发性高血压大鼠（SHR）和正常血压的Wistar - Kyoto（WKY）大鼠中，测量了降钙素基因相关肽（CGRP）在脑和脊髓各区域的浓度。WKY大鼠中CGRP浓度最高的部位是脊髓（172±9 pmol/g），其次是延髓/脑桥（88±5 pmol/g）。其余区域的分布相对顺序为：下丘脑（12.6±0.8 pmol/g） = 纹状体＞丘脑＞中脑 = 海马＞皮质（2.1±0.3 pmol/g）。小脑中CGRP的浓度处于检测灵敏度水平（0.5 pmol/g）。SHR品系中的分布相对顺序基本相同。然而，与WKY大鼠相比，SHR在海马（-47%）、纹状体（-49%）、延髓/脑桥（-24%）以及脊髓（-24%）中的CGRP水平显著较低。在年龄匹配更年轻（16 - 17周龄）的大鼠中，SHR脊髓和延髓/脑桥中的CGRP浓度也低于WKY大鼠。CGRP是一种假定的神经递质，当经中枢或外周给药时，具有强大的心血管效应。这种肽水平的降低可能是SHR品系心血管和/或行为异常的一个重要因素。
